A patient with peptic ulcer disease (PUD) is prescribed Carafate (sucralfate). What is the primary action of this medication in managing PUD?
Carafate neutralizes gastric acid to reduce irritation.
Carafate enhances gastric emptying to prevent reflux.
Carafate inhibits proton pumps to decrease acid production.
Carafate forms a protective barrier over the ulcer site.
The Correct Answer is D
Rationale:
A. Carafate (sucralfate) does not neutralize gastric acid. Unlike antacids, it does not chemically alter the pH of the stomach. While antacids temporarily reduce acid and provide symptomatic relief, sucralfate’s action is protective rather than neutralizing, focusing on shielding the ulcer from the harmful effects of acid, pepsin, and bile salts.
B. Carafate does not enhance gastric emptying or affect gastrointestinal motility. Prokinetic agents, such as metoclopramide, are used to increase gastric emptying and prevent reflux, but sucralfate’s mechanism is local mucosal protection, not altering the rate at which food or secretions move through the GI tract.
C. Carafate does not inhibit proton pumps or reduce gastric acid production systemically. Proton pump inhibitors (PPIs), like omeprazole, block the hydrogen-potassium ATPase enzyme in gastric parietal cells to suppress acid secretion. Sucralfate’s mechanism is mechanical and local, forming a protective barrier over the ulcer site rather than decreasing acid production.
D. Sucralfate forms a protective barrier over the ulcer site, binding to exposed proteins in the ulcer base to create a viscous, adhesive coating. This protective layer shields the ulcer from gastric acid, digestive enzymes, and bile salts, allowing the mucosal tissue to heal naturally while reducing pain and irritation. This barrier remains intact for several hours, making timing of administration important.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Rationale:
A. Encouraging the patient to eat solid foods may be appropriate once vomiting has subsided, but during active gastroenteritis with persistent vomiting and diarrhea, oral intake is often insufficient to prevent dehydration. Relying on food alone does not address acute fluid loss.
B. Initiating intravenous (IV) fluid therapy is the priority intervention. Persistent vomiting and diarrhea can lead to rapid fluid and electrolyte loss, resulting in hypovolemia, hypotension, tachycardia, and potential shock. IV fluids provide immediate restoration of circulating volume, correct electrolyte imbalances, and prevent life-threatening complications.
C. Administering antiemetics can help reduce nausea and vomiting, but it does not correct the underlying fluid deficit. While controlling vomiting supports oral intake, IV fluid replacement is more urgent to stabilize the patient.
D. Monitoring daily weight is useful for tracking fluid balance, but it is a secondary assessment tool. It does not intervene in acute hypovolemia and cannot replace prompt fluid resuscitation.
Correct Answer is D
Explanation
Rationale:
A. Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, and sleep disturbances, but it is not directly associated with the autoimmune manifestations of rheumatoid arthritis or the presence of dry eyes and mouth.
B. Raynaud’s phenomenon involves episodic vasospasm of the fingers and toes, causing color changes and discomfort with cold exposure. While it can occur in autoimmune conditions, it does not explain the hallmark symptoms of dry eyes and dry mouth.
C. Osteoporosis is a skeletal complication that may develop in rheumatoid arthritis patients due to chronic inflammation, corticosteroid use, or decreased mobility. However, it does not present with sicca symptoms (dry eyes and mouth).
D. Sjogren’s syndrome is an autoimmune disorder that often occurs secondary to rheumatoid arthritis. It is characterized by exocrine gland dysfunction, leading to dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). Early recognition is important to prevent dental caries, oral infections, and ocular complications, and to manage systemic involvement appropriately.
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