A patient with peptic ulcer disease (PUD) is prescribed Carafate (sucralfate). What is the primary action of this medication in managing PUD?
Carafate neutralizes gastric acid to reduce irritation.
Carafate enhances gastric emptying to prevent reflux.
Carafate inhibits proton pumps to decrease acid production.
Carafate forms a protective barrier over the ulcer site.
The Correct Answer is D
Rationale:
A. Carafate (sucralfate) does not neutralize gastric acid. Unlike antacids, it does not chemically alter the pH of the stomach. While antacids temporarily reduce acid and provide symptomatic relief, sucralfate’s action is protective rather than neutralizing, focusing on shielding the ulcer from the harmful effects of acid, pepsin, and bile salts.
B. Carafate does not enhance gastric emptying or affect gastrointestinal motility. Prokinetic agents, such as metoclopramide, are used to increase gastric emptying and prevent reflux, but sucralfate’s mechanism is local mucosal protection, not altering the rate at which food or secretions move through the GI tract.
C. Carafate does not inhibit proton pumps or reduce gastric acid production systemically. Proton pump inhibitors (PPIs), like omeprazole, block the hydrogen-potassium ATPase enzyme in gastric parietal cells to suppress acid secretion. Sucralfate’s mechanism is mechanical and local, forming a protective barrier over the ulcer site rather than decreasing acid production.
D. Sucralfate forms a protective barrier over the ulcer site, binding to exposed proteins in the ulcer base to create a viscous, adhesive coating. This protective layer shields the ulcer from gastric acid, digestive enzymes, and bile salts, allowing the mucosal tissue to heal naturally while reducing pain and irritation. This barrier remains intact for several hours, making timing of administration important.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Rationale:
A. Scheduling serological testing for Lyme disease may be part of the diagnostic process, but early testing is often unreliable because antibodies may not be detectable in the first few weeks after infection. Waiting for test results can delay treatment and increase the risk of complications.
B. Assessing for neurological involvement, such as facial palsy, is important in later stages of Lyme disease. While the nurse should monitor for these signs, it is not the immediate priority in a client with early localized disease and a characteristic rash.
C. Administering a prescribed dose of doxycycline is the most appropriate initial action. Early antibiotic treatment for Lyme disease, especially when a bull’s-eye rash (erythema migrans) is present, is critical to prevent progression to more serious systemic manifestations, including neurological, cardiac, or musculoskeletal complications. Prompt initiation of therapy is more important than waiting for confirmatory testing.
D. Initiating a discussion about safe hiking practices is valuable for health promotion and prevention, but it does not address the client’s immediate need for treatment. Education can be provided after initiating therapy.
Correct Answer is A
Explanation
Rationale:
A. Administering intravenous fluids is the immediate priority for a patient with signs of a significant gastrointestinal bleed such as hypotension, tachycardia, and melena, which indicate hypovolemia and possible hemorrhagic shock. Rapid fluid resuscitation helps restore circulating blood volume, improve blood pressure, and maintain perfusion to vital organs. According to emergency nursing priorities (ABCs and circulation), hemodynamic stabilization must occur before diagnostic or definitive treatments.
B. Preparing the patient for an endoscopic examination is important for identifying and treating the bleeding source; however, it is not the initial priority in an unstable patient. Endoscopy requires that the patient be hemodynamically stabilized first, as hypotension increases the risk of complications during the procedure.
C. Inserting a nasogastric tube may help assess for ongoing upper GI bleeding, but it is not a priority intervention in a patient who is already showing clear signs of significant bleeding and instability. NG tube placement can also cause discomfort and does not address the life-threatening issue of volume loss.
D. Proton pump inhibitors help reduce gastric acid secretion and promote clot stability, but they do not act immediately to correct hypotension or tachycardia. PPIs are typically administered after initial stabilization and often via the IV route, making them a secondary intervention rather than the first priority.
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