Autoimmunity is...
misdirected response to self-antigens
over response to foreign antigens
misdirected response to foreign antigens
over response to self-antigens
The Correct Answer is A
A. misdirected response to self-antigens: Autoimmunity is an immune response directed against self-antigens, i.e., the immune system mistakenly targets the body’s own tissues.
B. over response to foreign antigens: This describes hypersensitivity or exaggerated responses to foreign antigens, not autoimmunity.
C. misdirected response to foreign antigens: This would be an inappropriate response to non-self (again hypersensitivity/allergy), not autoimmunity.
D. over response to self-antigens: While autoimmune disease involves harmful responses to self, the key defining feature is a response against self-antigens (misdirected recognition); “over response” is less precise.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
A. apoptosis: Apoptosis is programmed cell death with cell shrinkage, chromatin condensation and membrane-bounded apoptotic bodies - it does not cause the severe swelling and organelle breakdown described.
B. necrosis: Necrosis is pathological cell death characterized by cell swelling, rupture, loss of membrane integrity and organelle breakdown (often accompanied by inflammation), as seen after an MI.
C. adaptation: Adaptation refers to reversible cellular changes (atrophy, hypertrophy, metaplasia, hyperplasia) that help the cell survive - not the irreversible swelling/degeneration described.
D. pathologic calcification: Pathologic calcification is deposition of calcium salts in dead or dying tissue (dystrophic) or in normal tissue with hypercalcemia (metastatic) - it is a process that can follow necrosis, not the direct term for the cell swelling/organellar breakdown.
Correct Answer is D
Explanation
A. regeneration: Regeneration replaces lost cells with the same cell type (restores normal tissue) and usually does not produce a scar when full regeneration occurs.
B. remodeling: Remodeling is the maturation and reorganization of the repair tissue (collagen), which shapes the scar but is part of the healing process rather than the initial cause of scarring.
C. granulation: Granulation tissue is rich in new capillaries and fibroblasts and is a stage in healing that precedes scar formation, but granulation itself is not the final scar.
D. fibrous connective tissue repair: Scar formation results from replacement of normal tissue by fibrous (collagenous) connective tissue-i.e., fibrous connective tissue repair (repair rather than regeneration).
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