Calcipotriene (SORILUX) foam, 0.005% w/w, is supplied in containers holding 60 g of product. (1) is the number of milligrams of calcipotriene per container. Round answer to the nearest whole number. Do not include units.

Albuterol is a sympathomimetic bronchodilator categorized as a short-acting beta-2 agonist (SABA). It selectively stimulates beta-2 receptors in the lungs to induce smooth muscle relaxation via adenylate cyclase activation. This increases intracellular cAMP levels, effectively reversing acute bronchoconstriction in asthma or COPD patients. Side effects commonly include tachycardia, tremors, and palpitations due to transient stimulation of beta-1 and skeletal muscle receptors.

Rationale:

A. ProAir HFA is the correct answer as it is a brand-name formulation of albuterol sulfate. It utilizes a metered-dose inhaler with hydrofluoroalkane propellant to deliver the medication directly to the bronchioles. This product is the gold standard for providing rapid relief of respiratory distress. It is frequently prescribed for exercise-induced bronchospasm and acute asthma exacerbations.

B. Primatene Mist contains epinephrine as the active ingredient, which is a non-selective alpha and beta-adrenergic agonist. While it provides bronchodilation, it lacks the beta-2 selectivity found in albuterol and has a higher risk of systemic cardiovascular stimulation. It is an over-the-counter medication and is not a formulation of albuterol.

C. Asthmanefrin contains racepinephrine, which is a racemic mixture of epinephrine. It is delivered via an atomizer but is not considered a SABA like albuterol due to its non-selective adrenergic profile. It is primarily used for temporary relief of bronchial asthma symptoms but does not contain the specific albuterol molecule.

D. Xopenex HFA contains levalbuterol, which is the (R)-enantiomer of albuterol. While structurally related, it is a purified form that removes the (S)-isomer, which is thought to be clinically inactive or potentially pro-inflammatory. Therefore, while it acts similarly, the active ingredient is levalbuterol, not racemic albuterol, making this choice technically incorrect.

E. Xopenex Concentrate is the nebulized solution form of levalbuterol. Like the HFA version, it specifically provides the single-isomer levalbuterol for inhalation therapy. It is used for patients who cannot effectively use a handheld inhaler or require high-dose therapy in a clinical setting. It does not contain standard racemic albuterol.

Step 1 is to identify the definition of percentage weight-in-volume (% w/v)

Percentage w/v = (grams of drug ÷ 100 mL of solution)

Step 2 is to convert the given concentration (mg/mL) into grams per milliliter

10 mg ÷ 1,000 = 0.01

Result at this step = 0.01 g/mL

Step 3 is to calculate the amount of drug in grams per 100 mL

(0.01 × 100) = 1

Result at this step = 1 g per 100 mL

Step 4 is to express this as a percentage

1 g per 100 mL = 1%

Result at this step = 1%