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Localized hypoxia occurs in rheumatoid arthritis because of:

A.

Joint immobilization

B.

Vasculitis

C.

Blockage of veins resulting in decrease oxygen delivery

D.

Release of synovial enzymes

Answer and Explanation

The Correct Answer is B

A. Joint immobilization may contribute to overall dysfunction but is not the primary cause of localized hypoxia in rheumatoid arthritis.

B. Vasculitis, or inflammation of blood vessels, can lead to localized hypoxia by reducing blood flow to affected areas, contributing to tissue damage in rheumatoid arthritis.

C. While blockage of veins can contribute to localized hypoxia, it is more related to vasculitis in this condition.

D. The release of synovial enzymes may contribute to joint damage but does not directly cause localized hypoxia.


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Related Questions

Correct Answer is A

Explanation

A. Hypertrophy refers to the increase in the size of cells, leading to an increase in the size of the organ or tissue, which is evident during pregnancy as the uterus enlarges.

B. Atrophy involves a decrease in cell size, leading to a reduction in tissue mass, which is not applicable to pregnancy.

C. Metaplasia is a process where one differentiated cell type is replaced by another, typically in response to chronic irritation or inflammation, not seen in normal pregnancy.

D. Dysplasia refers to abnormal development of cells, which is not a characteristic of a normal physiological process like pregnancy.

Correct Answer is B

Explanation

A. The pannus is a pathological feature that forms over the synovial membrane, but tissue destruction primarily begins in the synovial membrane itself.

B. The synovial membrane becomes inflamed and thickened in rheumatoid arthritis, leading to destruction of the surrounding joint structures, making it the primary site of tissue damage.

C. While articular cartilage is affected, it is a secondary effect of the inflammatory processes originating in the synovial membrane.

D. Ligaments and tendons can be affected in RA but are not the primary sites of destruction.

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