What is the term for a medication tablet that can be split or crushed?

A. Extracellular: The extracellular space refers to all fluid outside the cells, including interstitial fluid (surrounding tissues) and intravascular fluid (within blood vessels). It is critical for nutrient transport, waste removal, and maintaining fluid and electrolyte balance.

B. Vascular: Vascular refers specifically to the blood vessels and the fluid contained within them (plasma). It is only a part of the extracellular compartment, not the entire space outside cells.

C. Cytoplasmic: Cytoplasmic describes the fluid and organelles contained within the cell membrane, also known as the intracellular space. It is not outside the cell.

D. Intracellular: Intracellular refers to the space within the cell. This compartment contains cytoplasm and organelles and is distinct from the extracellular space.

A. Chew the gum briefly: Nicotine gum is designed to be chewed slowly until a tingling or peppery taste is noticed, then “parked” between the cheek and gum to allow nicotine absorption through the oral mucosa. Brief, repeated chewing releases nicotine gradually, enhancing effectiveness and reducing gastrointestinal side effects.

B. Swallow the gum whole: Swallowing nicotine gum prevents absorption through the oral mucosa and can increase gastrointestinal upset. The intended route of absorption is buccal, not gastrointestinal.

C. Crush the gum with tools before chewing: Crushing the gum is unnecessary and can release nicotine too quickly, increasing the risk of side effects such as nausea, dizziness, or palpitations. The gum is formulated for gradual release when chewed properly.

D. Dissolve the gum completely in the mouth: Letting the gum dissolve without chewing does not effectively break the outer shell and limits nicotine release. Proper chewing is required to initiate the pharmacologic effect.