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Where do most RBCs die?

A.

Stomach and small intestine

B.

Lymph nodes and thymus

C.

Red bone marrow

D.

Stomach and liver

E.

Spleen and liver

Answer and Explanation

The Correct Answer is E

A. Stomach and small intestine: the GI tract is not the normal major site of senescent RBC destruction.
B. Lymph nodes and thymus: lymph nodes filter lymph and the thymus is for T-cell maturation; they are not primary sites for normal RBC clearance.
C. Red bone marrow: red marrow produces RBCs and may phagocytose some defective cells, but it is not the main location where most senescent RBCs are removed.
D. Stomach and liver: the liver (Kupffer cells) does phagocytose some RBCs, but the stomach is not a primary site for RBC removal.
E. Spleen and liver: most senescent or damaged RBCs are removed by splenic macrophages (the spleen is the primary site) with additional clearance by liver (Kupffer) cells; RBC lifespan ≈120 days.


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Related Questions

Correct Answer is D

Explanation

A. CP: Creatine phosphate (phosphocreatine) is an energy-reserve molecule in muscle that donates phosphate to ADP to regenerate ATP; it is not a second messenger in hormone signal transduction and would not appear as the intracellular signaling oval shown.

B. DPG: 2,3-diphosphoglycerate (2,3-DPG) is an RBC metabolite that modulates hemoglobin’s O₂ affinity; it is not produced as a cytoplasmic second messenger following receptor activation.

C. PEP: Phosphoenolpyruvate (PEP) is a glycolytic intermediate involved in metabolism, not a hormone-activated intracellular signaling molecule.

D. CAMP: Cyclic AMP (cAMP) is a common second messenger produced by adenylate cyclase after many peptide hormones bind cell-surface receptors; the diagram’s small oval (C) inside the cytoplasm leading to downstream effects (D) fits cAMP.

Correct Answer is E

Explanation

A. Type AB: Type AB has both A and B antigens.
B. Type O: Type O has neither A nor B antigens.
C. Either Type A or Type B, there is not enough information to distinguish between them: Presence of A antigens and absence of B antigens identifies Type A (unless testing error or weak expression, but standardly it’s Type A).
D. Type B: Type B would have B antigens (and no A).
E. Type A: A antigens present and B antigens absent - Type A.

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