Which of the following correctly lists the sequence of steps that occur during hemostasis in response to a damaged blood vessel?

a) Synthesis of thyroglobulin by the follicular cells: This occurs after iodide has been trapped and transported into the follicular lumen.

b) Oxidation of iodide by the follicular cells: This is a later step; iodide must first be trapped before it can be oxidized into iodine.

c) Coupling of T1 and T2: This is one of the final steps in T₃/T₄ synthesis where iodinated tyrosines are joined.

d) lodide trapping by the follicular cells

Iodide trapping is the first step, where follicular cells actively transport iodide from the bloodstream into the thyroid follicle using sodium-iodide symporters.

a) Decreased evidence of endocytosis: Endocytosis increases in hyperthyroidism as T3/T4 are actively removed from colloid.

b) Decreased evidence of lysosomal activity: Lysosomal activity increases to process thyroglobulin into active hormones.

c) A decrease in the size of the follicular cells: Follicular cells become taller (columnar) and more active, not smaller.

d) A decrease in the cross-sectional area occupied by the colloid: In hyperthyroidism (e.g., Graves' disease), the thyroid follicles are hyperactive, so colloid is used up rapidly, reducing the colloid area.

e) Decreased number of reabsorption lacunae: These increase in number as colloid is actively resorbed.