During erythropoiesis in the bone marrow, which is the last cell to have a nucleus?
erythrocytes
normoblasts
proerythroblasts
reticulocytes
The Correct Answer is B
a) Erythrocytes: These are mature red blood cells and do not have a nucleus.
b) Normoblasts: A normoblast is the last stage of red blood cell development that still has a nucleus. Once the nucleus is ejected, the cell becomes a reticulocyte and then matures into an erythrocyte.
c) Proerythroblasts: This is an earlier precursor stage that still has a nucleus but is not the final nucleated form.
d) Reticulocytes: Reticulocytes are immature RBCs that lack a nucleus but still contain RNA remnants.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
a) Lumen of follicle: Iodide is actively transported into follicular cells, then secreted into the follicular lumen, where it becomes oxidized and incorporated into thyroglobulin during the synthesis of thyroid hormones (T3 and T4).
b) Secretory vesicles inside follicular cells: These vesicles may contain thyroglobulin, but iodide is concentrated in the lumen for hormone synthesis.
c) Golgi apparatus of parafollicular cells: Parafollicular (C) cells produce calcitonin, not thyroid hormones.
d) Cytoplasm of follicular cells: While iodide is transported into the cytoplasm briefly, its major functional location is in the lumen.
Correct Answer is D
Explanation
a) Synthesis of thyroglobulin by the follicular cells: This occurs after iodide has been trapped and transported into the follicular lumen.
b) Oxidation of iodide by the follicular cells: This is a later step; iodide must first be trapped before it can be oxidized into iodine.
c) Coupling of T1 and T2: This is one of the final steps in T₃/T₄ synthesis where iodinated tyrosines are joined.
d) lodide trapping by the follicular cells
Iodide trapping is the first step, where follicular cells actively transport iodide from the bloodstream into the thyroid follicle using sodium-iodide symporters.
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