Which of the following disorders is a deficiency of factor VIII?
Hemophilia A
Hemophilia B
Christmas disease
Sickle cell disease
The Correct Answer is A
A. Hemophilia A: Hemophilia A is caused by a deficiency of factor VIII, leading to problems with blood clotting.
B. Hemophilia B: Hemophilia B is caused by a deficiency of factor IX, not factor VIII.
C. Christmas disease: Christmas disease is another name for Hemophilia B, which is caused by a deficiency of factor IX.
D. Sickle cell disease: Sickle cell disease is a genetic disorder affecting hemoglobin, not a clotting factor deficiency.
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Related Questions
Correct Answer is C
Explanation
A. Clotting is not directly related to the destruction of red blood cells.
B. Cyanosis refers to a bluish discoloration of the skin due to poor circulation or inadequate oxygenation, which is not directly indicative of red blood cell destruction.
C. Jaundice is the yellowing of the skin and eyes caused by the buildup of bilirubin, a byproduct of the destruction of red blood cells, which is a common symptom of hemolytic anemia.
D. Bleeding is not a symptom associated with the destruction of red blood cells but rather a lack of clotting factors or platelets.
Correct Answer is A
Explanation
A. This response accurately describes the pathophysiology of sickle cell crisis. During a crisis, sickled red blood cells clump together, leading to microvascular occlusion and impaired blood flow to tissues, resulting in pain.
B. Bleeding in the joints is not a characteristic feature of sickle cell crisis. It may occur in other conditions such as hemophilia or osteoarthritis but not in sickle cell crisis.
C. Disturbance in cellular metabolism is not the primary mechanism underlying the pain experienced during sickle cell crisis.
D. Bone marrow expansion with sickled cells may contribute to bone pain in sickle cell disease, but it is not the primary cause of pain during a sickle cell crisis.
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