Which of the following disorders is a deficiency of factor VIII?
Hemophilia A
Hemophilia B
Christmas disease
Sickle cell disease
The Correct Answer is A
A. Hemophilia A: Hemophilia A is caused by a deficiency of factor VIII, leading to problems with blood clotting.
B. Hemophilia B: Hemophilia B is caused by a deficiency of factor IX, not factor VIII.
C. Christmas disease: Christmas disease is another name for Hemophilia B, which is caused by a deficiency of factor IX.
D. Sickle cell disease: Sickle cell disease is a genetic disorder affecting hemoglobin, not a clotting factor deficiency.
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Related Questions
Correct Answer is ["A","B","G"]
Explanation
A. Severe pain is a hallmark manifestation of a sickle cell crisis due to vaso-occlusion and tissue ischemia.
B. Fever can occur during a sickle cell crisis, often indicating an underlying infection or inflammatory response.
C. Normal blood counts are not typical during a sickle cell crisis; patients often exhibit anemia, leukocytosis, and thrombocytosis.
D. Clear urine is not a common manifestation of a sickle cell crisis; hematuria or dark-colored urine may occur due to hemolysis or kidney damage.
E. Increased energy levels are not typical during a sickle cell crisis; patients often experience fatigue and malaise.
F. Normal oxygen saturation levels may occur in some patients during a sickle cell crisis, but it is not a consistent finding.
G. Jaundice is common in sickle cell crisis due to hemolysis of red blood cells, leading to an increase in bilirubin levels.
Correct Answer is C
Explanation
A. Presence of Bence-Jones protein in the urine is indicative of multiple myeloma, but hypercalcemia is a more urgent issue to address.
B. Severe back pain is common in multiple myeloma due to bone involvement, but it is not as immediately life-threatening as hypercalcemia.
C. Elevated serum calcium levels (hypercalcemia) are a common complication of multiple myeloma and can lead to various complications, including kidney damage, altered mental status, and cardiac arrhythmias. Therefore, it is crucial to report significantly elevated serum calcium levels promptly to the health care provider for appropriate management.
D. Patient reports no stool for 5 days may indicate constipation, which is important to address but is not as urgent as hypercalcemia in the context of multiple myeloma.
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