Which of the following hormones acting on the collecting duct is most responsible for retaining sodium ions in the blood?
atrial natriuretic peptide
parathyroid hormone
antidiuretic hormone
aldosterone
renin
The Correct Answer is D
A. atrial natriuretic peptide: This hormone is released by the heart in response to atrial stretch and actually promotes sodium excretion rather than retention. It inhibits the release of renin and aldosterone to lower blood pressure. It acts as a physiological antagonist to the sodium-retaining mechanisms of the kidney.
B. parathyroid hormone: The primary target of this hormone in the renal system is the distal convoluted tubule where it stimulates calcium reabsorption. It also inhibits phosphate reabsorption in the proximal tubule to manage mineral homeostasis. It does not play a significant role in systemic sodium ion retention.
C. antidiuretic hormone: Also known as vasopressin, this hormone primarily regulates water permeability in the collecting duct by inserting aquaporin-2 channels. While it affects osmolarity, it does not directly transport sodium ions. Its main function is the regulation of free water clearance to control plasma concentration.
D. aldosterone: This mineralocorticoid acts on the principal cells of the collecting duct to upregulate apical sodium channels and basolateral sodium-potassium pumps. This results in significant sodium reabsorption back into the blood, followed osmotically by water. It is the definitive hormone for long-term sodium balance regulation.
E. renin: Renin is a proteolytic enzyme, not a hormone that acts directly on the collecting duct to transport ions. It initiates the biochemical cascade that eventually produces angiotensin 2 and aldosterone. Its role is regulatory and enzymatic rather than being a direct transport-stimulating effector.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is E
Explanation
A. dissolve the mucosa of the vagina: The vaginal mucosa is a stratified squamous epithelium designed to withstand mechanical friction. The enzymes within the sperm head are not adapted to break down this type of protective tissue. The sperm must swim through the vagina rather than chemically dissolve its lining.
B. dissolve the mucosa of the uterus: Sperm move through the uterus via their own motility and uterine contractions toward the uterine tubes. The enzymes in the acrosome are not utilized for navigating the uterine cavity. They are preserved for the final interaction with the secondary oocyte in the ampulla.
C. penetrate the vagina: Penetration of the vagina is achieved mechanically during coitus and by the flagellar motion of the sperm. Chemical enzymes are unnecessary for this stage of the reproductive process. The acrosomal reaction is a highly specific event triggered only upon contact with the egg.
D. dissolve the stickiness of the semen: The liquefaction of semen is primarily handled by proteolytic enzymes produced by the prostate gland, such as prostate-specific antigen. These enzymes act extracellularly in the ejaculate. The acrosome is an intracellular organelle whose enzymes remain sequestered until the sperm reaches the egg.
E. penetrate the barriers surrounding the ovum: The acrosome is a cap-like vesicle containing hyaluronidase and acrosin. These enzymes are released during the acrosomal reaction to digest the zona pellucida and corona radiata. This allows the sperm nucleus to reach the plasma membrane of the secondary oocyte for fusion.
Correct Answer is E
Explanation
A. site of gestation: Gestation refers to the period of fetal development from conception to birth, which occurs entirely within the protective environment of the uterine cavity. The uterus provides the necessary space and blood supply for the growing fetus. It is the definitive anatomical location for pregnancy in mammals.
B. site of parturition(childbirth): The uterus contains the myometrium, a powerful layer of smooth muscle capable of generating the rhythmic contractions required to expel the fetus. During labor, these contractions push the infant through the cervix and vaginal canal. The uterus is the primary mechanical driver of the birthing process.
C. site of implantation: After fertilization in the uterine tube, the developing blastocyst travels to the uterus to embed itself into the vascularized endometrium. This attachment is essential for the establishment of the placenta and the survival of the embryo. Implantation marks the beginning of the physiological connection between mother and offspring.
D. site of menstruation: If fertilization does not occur, the functional layer of the endometrium is shed in response to falling levels of progesterone. This tissue and associated blood exit the body through the cervix and vagina as the menstrual flow. The uterus is the organ responsible for this periodic cyclical shedding.
E. site of ovulation: Ovulation is the biological process where a secondary oocyte is released from a mature follicle within the ovary. The uterus receives the egg after it has been ovulated, but it is not the site where the release occurs. Ovulation is strictly an ovarian function regulated by the LH surge.
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