Which of the following is/are FDA-approved labeled indication(s) for Metoclopramide Hydrochloride? Select all that apply.

A. Chlorhexidine possesses broad-spectrum antimicrobial activity but is not a primary treatment for oral herpes virus. It does not inhibit viral DNA polymerase like acyclovir. This agent is not FDA-approved for the management of viral infections.

B. Gingivitis is a labeled indication for chlorhexidine gluconate oral rinse. It provides antimicrobial activity by disrupting the plasma membrane of bacterial cells. This reduces dental plaque and gingival inflammation between dental visits.

C. Vaginal candidiasis is typically managed with antifungal agents like fluconazole or miconazole. Chlorhexidine is not indicated for the treatment of fungal infections within the vaginal vault. Its therapeutic use is restricted to topical or oral mucosal applications.

D. Cryptococcal meningitis is a severe fungal infection of the central nervous system requiring systemic amphotericin B. Chlorhexidine does not cross the blood-brain barrier and lacks the necessary systemic distribution. It is not an approved treatment for meningitis.

A. Lidoderm is the brand name for the 5 percent transdermal patch containing lidocaine. It functions as a local anesthetic by blocking voltage-gated sodium channels in neuronal membranes. This stabilizes the membrane and inhibits the initiation and conduction of nociceptive nerve impulses.

B. Actos is the proprietary brand name for pioglitazone, a thiazolidinedione used in type 2 diabetes mellitus. It acts as an agonist for the peroxisome proliferator-activated receptor gamma to improve insulin sensitivity. It is pharmacologically unrelated to transdermal lidocaine preparations.

C. Lithobid is the brand name for a slow-release formulation of lithium carbonate. It is used primarily as a mood stabilizer in the management of bipolar disorder. It modulates neurotransmission via various intracellular signaling pathways and is not a local anesthetic.

D. Dilantin is the brand name for phenytoin, a hydantoin derivative used as an antiepileptic medication. It stabilizes neuronal membranes by promoting sodium efflux or decreasing sodium influx during generation of nerve impulses. It is not the brand name for lidocaine.