Which principle of pharmacokinetics must the nurse keep in mind when administering medication to an infant?.
Metabolism of drug by the kidneys is slower, so reduced dosage is needed.
Absorption of oral medications is more predictable but more rapid than in adults.
There's an increased risk of toxicity with use of topical agents.
Protein binding of drugs is greater than in adults.
The Correct Answer is C
Choice A rationale:
While it’s true that infants have slower drug metabolism, this is generally due to liver immaturity, not kidney function.
Choice B rationale:
Absorption of oral medications in infants can be unpredictable due to their immature digestive systems.
Choice C rationale:
Infants do have an increased risk of toxicity with the use of topical agents because their skin is thinner and more permeable.
Choice D rationale:
Protein binding of drugs is actually less in infants than in adults, not greater.
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Related Questions
Correct Answer is C
Explanation
Choice A rationale:
The frequency of drug administration doesn’t necessarily determine the therapeutic range.
Choice B rationale:
Protein binding is not directly related to the frequency of drug administration.
Choice C rationale:
Drug A has a longer half-life than drug B. This is because drugs with longer half-lives need to be administered less frequently.
Choice D rationale:
The toxicity of a drug is not determined by the frequency of its administration.
Correct Answer is D
Explanation
Choice A rationale:
Protein binding does not inactivate the drug. Instead, it can affect the drug’s distribution and bioavailability.
Choice B rationale:
Protein binding does not directly increase the risk of an allergic reaction. Allergic reactions are typically immune responses to a drug, not a result of protein binding.
Choice C rationale:
An idiosyncratic reaction is an unusual or unexpected reaction to a drug, which is not related to protein binding.
Choice D rationale:
Protein binding can lead to the accumulation of the drug. Drugs often cannot cross membranes mainly due to the high molecular mass of the drug-protein complex, resulting in the accumulation of the active compounds.
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