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Which aspect of pharmacokinetics should the nurse be most concerned with when caring for a patient with abnormal functioning of hepatic enzymes?.

Absorption.

Distribution.

Excretion.

Metabolism.

Answer and Explanation

The Correct Answer is D

Choice A rationale:

Absorption is not primarily affected by the functioning of hepatic enzymes.

Choice B rationale:

Distribution is not the main concern when dealing with abnormal functioning of hepatic enzymes.

Choice C rationale:

Excretion is mainly a function of the kidneys, not the liver.

Choice D rationale:

Metabolism is the aspect of pharmacokinetics most affected by the functioning of hepatic enzymes. The liver plays a crucial role in the metabolism of drugs.

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Correct Answer is ["83"]

Explanation

Step 2 is to substitute these values into the formula for calculating the manual IV flow rate: Flow Rate ® = (V ÷ T) × C

Step 3 is to perform the calculation: R = (250 mL ÷ 30 min) × 10 gtt/mL R = 83.33 gtt/min

Since we need to round off to the nearest whole number, the flow rate is 83 gtt/min.

A. Allergic reaction. B. Displacement. C. Accumulation. D. Drug interaction.

Correct Answer is D

Explanation

Choice A rationale:
An allergic reaction refers to an immune response to a foreign substance. It does not describe the interaction between an antacid and ketoconazole.
Choice B rationale:
Displacement refers to one drug replacing another at the drug-binding site on proteins, altering the distribution of the displaced drug. It does not describe the interaction between an antacid and ketoconazole.
Choice C rationale:
Accumulation refers to the buildup of a drug in the body due to inadequate metabolism or excretion. It does not describe the interaction between an antacid and ketoconazole.
Choice D rationale:
A drug interaction occurs when the effect of one drug is altered by the administration of another drug. Antacids can slow the dissolution and absorption of ketoconazole, which is a type of drug interaction.

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Which aspect of pharmacokinetics should the nurse be most concerned with when caring for a patient with abnormal functioning of hepatic enzymes?.

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

Correct Answer is ["83"]

Explanation

A patient is taking an antacid concurrently with ketoconazole. The antacid inhibits the dissolution of ketoconazole. Which term accurately describes this result?.

Correct Answer is D

Explanation

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