Which aspect of pharmacokinetics should the nurse be most concerned with when caring for a patient with abnormal functioning of hepatic enzymes?.

Choice A rationale:

Protein needs do not necessarily accentuate with age. In fact, they may decrease due to reduced physical activity and metabolic rate.

Choice B rationale:

Total fat content does not decrease with age. It’s common for fat distribution to change and increase in certain areas.

Choice C rationale:

Total body water does not increase with age. It usually decreases due to the loss of muscle mass and increase in fat content.

Choice D rationale:

Lean body mass decreases as a person ages. This is a common phenomenon due to changes in cells and tissues.

Choice A rationale:
The blood flow of the mucous lining of the stomach and intestines can affect how quickly a drug is absorbed.
Choice B rationale:
Drug distribution refers to how a drug spreads throughout the body, not its absorption in the gastrointestinal tract.
Choice C rationale:
Enzyme activity can affect how a drug is metabolized and absorbed.
Choice D rationale:
Gastric pH can affect drug absorption as some drugs are better absorbed in an acidic environment, while others are better absorbed in an alkaline environment.
Choice E rationale:
Gastric emptying time can affect drug absorption. Drugs may stay in contact with the absorptive tissue longer if the gastric emptying time is slower, allowing for increased absorption.