Which factors affect the gastrointestinal absorption of medicines? (Select all that apply.) Select 4 options.
(Select All that Apply.).
Blood flow of the mucous lining of the stomach and intestines.
Drug distribution.
Enzyme activity.
Gastric pH.
Gastric emptying time.
Correct Answer : A,C,D,E
Choice A rationale:
The blood flow of the mucous lining of the stomach and intestines can affect how quickly a drug is absorbed.
Choice B rationale:
Drug distribution refers to how a drug spreads throughout the body, not its absorption in the gastrointestinal tract.
Choice C rationale:
Enzyme activity can affect how a drug is metabolized and absorbed.
Choice D rationale:
Gastric pH can affect drug absorption as some drugs are better absorbed in an acidic environment, while others are better absorbed in an alkaline environment.
Choice E rationale:
Gastric emptying time can affect drug absorption. Drugs may stay in contact with the absorptive tissue longer if the gastric emptying time is slower, allowing for increased absorption.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale:
One-eighth to one-fourth of the normal adult dose is not typically used when initiating drug therapy in elderly adults. This range might be too low to be effective.
Choice B rationale:
One-fourth to one-third of the normal adult dose is also not typically used when initiating drug therapy in elderly adults. This range might still be too low to be effective.
Choice C rationale:
One-half to three-fourths of the normal adult dose is not typically used when initiating drug therapy in elderly adults. This range might be too high and increase the risk of adverse effects.
Choice D rationale:
One-third to one-half of the normal adult dose is used when initiating drug therapy in elderly adults. This range is appropriate to balance efficacy and safety.
Correct Answer is D
Explanation
Choice A rationale:
Absorption is not primarily affected by the functioning of hepatic enzymes.
Choice B rationale:
Distribution is not the main concern when dealing with abnormal functioning of hepatic enzymes.
Choice C rationale:
Excretion is mainly a function of the kidneys, not the liver.
Choice D rationale:
Metabolism is the aspect of pharmacokinetics most affected by the functioning of hepatic enzymes. The liver plays a crucial role in the metabolism of drugs.
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