Which factors affect the gastrointestinal absorption of medicines? (Select all that apply.) Select 4 options.

(Select All that Apply.).

Blood flow of the mucous lining of the stomach and intestines.

Drug distribution.

Enzyme activity.

Gastric pH.

Gastric emptying time.

Answer and Explanation

Correct Answer : A,C,D,E

Choice A rationale:
The blood flow of the mucous lining of the stomach and intestines can affect how quickly a drug is absorbed.
Choice B rationale:
Drug distribution refers to how a drug spreads throughout the body, not its absorption in the gastrointestinal tract.
Choice C rationale:
Enzyme activity can affect how a drug is metabolized and absorbed.
Choice D rationale:
Gastric pH can affect drug absorption as some drugs are better absorbed in an acidic environment, while others are better absorbed in an alkaline environment.
Choice E rationale:
Gastric emptying time can affect drug absorption. Drugs may stay in contact with the absorptive tissue longer if the gastric emptying time is slower, allowing for increased absorption.

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Correct Answer is C

Explanation

Choice A rationale:

Decreased splanchnic blood flow can affect drug absorption and metabolism, but it does not directly increase the risk of gastric irritation from NSAIDs.

Choice B rationale:

Prolonged secretion of gastric acid can contribute to conditions like gastroesophageal reflux disease (GERD), but it is not the primary factor increasing the risk of gastric irritation from NSAIDs in older adults.

Choice C rationale:

Delayed gastric emptying is the correct answer. It allows drugs to stay in contact with the stomach lining for a longer time, which can increase the risk of gastric irritation from NSAIDs.

Choice D rationale:

Loss of cells from the gastric plexus can affect gastric function, but it is not directly linked to an increased risk of gastric irritation from NSAIDs.

A. Aged. B. Elderly. C. Adult. D. Older adult.

Correct Answer is D

Explanation

Choice A rationale:
The term “Aged” is not a specific life stage and can refer to anyone who is old, without specifying an age range.
Choice B rationale:
“Elderly” is often used to refer to individuals who are in their 80s or 90s, which is older than 653.
Choice C rationale:
“Adult” typically refers to individuals in the age range of 18 to 64 years, so a 65-year-old would not fall into this category.
Choice D rationale:
“Older adult” is a term often used to refer to individuals who are 65 years and older. So, the correct answer is Choice D, Older adult.

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Which factors affect the gastrointestinal absorption of medicines? (Select all that apply.) Select 4 options. (Select All that Apply.).

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Naxlex Comprehensive Predictor Exams

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