Pathophysiology
1. Infection Route
- Gastroenteritis is typically contracted by ingesting contaminated food or water that contains infectious agents such as bacteria, viruses, or parasites.
2. Attachment and Invasion
- Once inside the gastrointestinal tract, the infectious agents attach themselves to the lining of the stomach and intestines. They may have specialized structures or proteins that allow them to adhere to the cells.
3. Multiplication and Colonization
- After attachment, the infectious agents start to multiply rapidly. This leads to an increase in their population within the intestines, overwhelming the body's natural defenses.
4. Inflammation and Tissue Damage
- As the infectious agents multiply, they release toxins, enzymes, or other virulence factors. These substances can lead to inflammation of the gastrointestinal mucosa. Inflammatory responses can cause damage to the cells lining the stomach and intestines.
5. Disruption of Absorptive Functions
- The inflammation and damage to the mucosa can impair the normal absorptive functions of the intestines. This can result in malabsorption of nutrients, electrolytes, and water.
6. Activation of Immune Response
- The body recognizes the presence of foreign pathogens and mounts an immune response. Immune cells, such as white blood cells, are mobilized to the site of infection.
7. Release of Cytokines
- The immune response involves the release of signaling molecules called cytokines. These cytokines have various effects, including increasing inflammation, altering the permeability of blood vessels, and stimulating the production of mucus.
8. Symptom Manifestation
- The combined effects of inflammation, altered absorptive functions, and immune response lead to the characteristic symptoms of gastroenteritis, which include diarrhea, nausea, vomiting, abdominal cramps, fever, and sometimes dehydration.
9. Fluid and Electrolyte Imbalance
- The frequent diarrhea and vomiting can lead to significant fluid and electrolyte losses. This can result in dehydration and imbalances in electrolyte levels, which are particularly concerning, especially in vulnerable populations like infants and the elderly.
10. Resolution and Recovery
- With appropriate treatment and supportive care, the body's immune system eventually clears the infectious agents. The gastrointestinal mucosa begins to heal, and normal function is gradually restored.
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