146 lbs =___kg (Round to the nearest tenth & fill in the blank with the numerical value only)

A. "Increase your fluid intake to 2–3 liters per day.": Increased fluid intake helps dilute uric acid levels and promotes renal excretion, reducing the risk of kidney stones—a common complication in patients taking allopurinol. Maintaining hydration is a key part of long-term gout management.
B. "Discontinue the medication once symptoms improve.": Allopurinol is a maintenance medication meant to prevent gout flares by lowering uric acid levels over time. Stopping it when symptoms improve can lead to rebound hyperuricemia and recurrent attacks.
C. "Double the dose if a dose is missed.": Doubling a missed dose can increase the risk of toxicity, including skin rash, liver dysfunction, and hypersensitivity reactions. If a dose is missed, it should be taken as soon as remembered unless it's almost time for the next dose.
D. "Take the medication only during acute gout attacks.": Allopurinol is not intended for acute gout relief; it can actually worsen or trigger flares when initiated during an attack. It is used for chronic urate-lowering therapy and should be taken consistently.

A. "Opioid-induced constipation typically resolves on its own after a few weeks of treatment.": This is incorrect. Unlike other opioid side effects such as nausea or sedation, constipation does not typically resolve over time. It often persists and requires proactive management throughout opioid therapy.
B. "Avoid physical activity to prevent exacerbating your back pain.": While activity should be adjusted to the patient’s condition, light physical activity like walking actually helps stimulate bowel function. Complete avoidance of movement can worsen constipation.
C. "Start taking stool softeners along with your opioid medication.": This is the most appropriate advice. Prophylactic use of stool softeners or stimulant laxatives is recommended when initiating opioid therapy, as constipation is a nearly universal side effect due to slowed gastrointestinal motility.
D. "You should wait to see if constipation develops before taking any specific measures.": Waiting for constipation to develop can lead to discomfort and complications like fecal impaction. Preventive strategies should be started as soon as opioid treatment begins.