146 lbs =___kg (Round to the nearest tenth & fill in the blank with the numerical value only)

A. "All antipsychotic drugs carry an equal risk of causing movement-related side effects.": First-generation antipsychotics like Haloperidol are more likely to cause extrapyramidal symptoms due to their potent dopamine D2 receptor blockade. Second-generation antipsychotics carry a lower risk, making this statement inconsistent with clinical evidence.
B. "These side effects happen because this drug blocks dopamine in certain parts of my brain.": Extrapyramidal symptoms are primarily due to dopamine blockade in the nigrostriatal pathway, which regulates motor control. Interference in this region leads to tremors, rigidity, and other movement disorders.
C. "Taking other drugs with my Haloperidol can increase the risk of extrapyramidal symptoms.": Concurrent use of medications that also affect dopamine pathways or have sedative effects can increase the likelihood of developing EPS. Drug interactions are a significant factor in overall risk.
D. "Tardive dyskinesia occurs with prolonged use of an antipsychotic drug.": Long-term use of dopamine-blocking agents, especially at high doses, can lead to tardive dyskinesia. This condition involves involuntary movements and may be irreversible, particularly in older adults.

A. The Cytochrome P-450 Enzyme System: This system plays a major role in drug metabolism, particularly in the liver, but it does not significantly affect drug distribution. Its primary influence is on the biotransformation of drugs into active or inactive metabolites.
B. Renal function: Renal function primarily affects drug excretion. Impaired kidney function can lead to drug accumulation and toxicity but has a minimal direct effect on the distribution of drugs throughout tissues and organs.
C. Gastric pH: Gastric pH influences drug absorption in the gastrointestinal tract, especially for pH-sensitive drugs. However, it plays little to no role in the actual distribution of the drug once it enters systemic circulation.
D. Blood flow: Blood flow is the most significant factor affecting drug distribution. Highly perfused organs like the brain, liver, and kidneys receive drugs more quickly and in higher concentrations than poorly perfused tissues, influencing the onset and intensity of drug action.