A 38-year-old man has come into the urgent care center with severe hip pain after falling from a ladder at work. He says he has taken several pain pills over the past few hours but cannot remember how many he has taken. He hands the nurse an empty bottle of acetaminophen (Tylenol). The nurse is aware that the most serious toxic effect of acute acetaminophen overdose is which condition?

Choice A reason: This statement is false. Glucose: 88 mg/dL is a normal blood sugar level and does not indicate any problem with fluid or electrolyte balance¹.

Choice B reason: This statement is false. WBCs: 4000 is slightly below the normal range, but not significantly low. It may indicate a mild infection or inflammation, but not a serious fluid or electrolyte imbalance².

Choice C reason: This statement is false. K+: 3.4 mEq/L is slightly below the normal range, but not dangerously low. It may indicate a mild potassium deficiency, which can cause muscle weakness, but not restlessness or agitation.

Choice D reason: This statement is true. Na+: 154 mEq/L is above the normal range and indicates hypernatremia, or high blood sodium level. This can cause dehydration, confusion, restlessness, agitation, and seizures. It is a medical emergency that requires immediate treatment. Continuous tube feedings can increase the risk of hypernatremia if the formula is too concentrated or the fluid intake is inadequate⁵.

Choice A reason: This statement is false. A serum potassium level of 5.6 mEq/L is not a common side effect of furosemide. This value indicates hyperkalemia, or high blood potassium level, which can cause cardiac arrhythmias and muscle weakness. Furosemide is a loop diuretic that causes potassium loss, not retention.

Choice B reason: This statement is false. A serum sodium level of 142 mEq/L is not a common side effect of furosemide. This value is within the normal range of 135-145 mEq/L and does not indicate any problem with sodium balance. Furosemide is a loop diuretic that causes sodium loss, but it is usually compensated by the renin-angiotensin-aldosterone system.

Choice C reason: This statement is false. A serum sodium level of 138 mEq/L is not a common side effect of furosemide. This value is within the normal range of 135-145 mEq/L and does not indicate any problem with sodium balance. Furosemide is a loop diuretic that causes sodium loss, but it is usually compensated by the renin-angiotensin-aldosterone system.

Choice D reason: This statement is true. A serum potassium level of 2.8 mEq/L is a common side effect of furosemide. This value indicates hypokalemia, or low blood potassium level, which can cause cardiac arrhythmias, muscle weakness, and metabolic alkalosis. Furosemide is a loop diuretic that inhibits the reabsorption of sodium and potassium in the ascending loop of Henle, leading to potassium loss in the urine.