A 59-year-old woman with a history of breast cancer is taking tamoxifen to reduce recurrence risk. She is depressed and reports difficulty sleeping and hot flashes since initiating tamoxifen (a CYP2D6 substrate). Which of the following antidepressants is most appropriate?
Duloxetine (Cymbalta)
Venlafaxine (Effexor)
Bupropion (Wellbutrin)
Fluoxetine (Prozac)
The Correct Answer is B
Choice A reason: Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that can be used for depression and pain. However, it has moderate CYP2D6 inhibition, which may interfere with tamoxifen metabolism and reduce its efficacy.
Choice B reason: Venlafaxine is an SNRI with minimal CYP2D6 inhibition. It is effective for depression and also helps alleviate hot flashes, making it the most appropriate choice for this patient.
Choice C reason: Bupropion is a norepinephrine-dopamine reuptake inhibitor and a strong CYP2D6 inhibitor. It can significantly reduce the conversion of tamoxifen to its active metabolite, endoxifen, thereby compromising its therapeutic effect.
Choice D reason: Fluoxetine is a potent CYP2D6 inhibitor and should be avoided in patients taking tamoxifen due to the risk of reducing its efficacy in preventing breast cancer recurrence.
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Related Questions
Correct Answer is C
Explanation
Choice A reason: Escitalopram has a relatively short half-life and typically requires a 2-week washout period before initiating an MAOI to avoid serotonin syndrome.
Choice B reason: Sertraline also has a shorter half-life and does not require a 5-week washout. A 2-week period is generally sufficient.
Choice C reason: Fluoxetine has the longest half-life among SSRIs, with active metabolites that persist in the body for weeks. Due to this extended duration, a 5-week washout period is recommended before starting an MAOI to prevent serotonin toxicity.
Choice D reason: Paroxetine has a short half-life and would not necessitate a 5-week washout. A 2-week interval is typically adequate.
Correct Answer is A
Explanation
Choice A reason: Interpersonal therapy (IPT) is a structured, time-limited approach that focuses on improving interpersonal relationships and social functioning to alleviate depressive symptoms. It targets role transitions, grief, interpersonal disputes, and social deficits.
Choice B reason: Psychoanalysis is a long-term, intensive therapy that explores unconscious conflicts and childhood experiences. It is not time-limited and does not specifically focus on interpersonal issues related to depression.
Choice C reason: Cognitive behavioral therapy (CBT) addresses distorted thinking and maladaptive behaviors. While effective for depression, it does not primarily focus on interpersonal relationships.
Choice D reason: Supportive therapy provides emotional support and encouragement but lacks the structured, targeted approach of IPT. It is not specifically designed to address interpersonal factors in depression.
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