A long-term complication sees in Thalassemia major are associated to which of the following?

Fatigue

Deferoxamine usage

Immunosuppressive therapy

Hemochromatosis/Hemosiderosis

Answer and Explanation

The Correct Answer is D

Option A, "Fatigue," is a symptom of anemia but is not a long-term complication associated with Thalassemia major.

Option B, "Deferoxamine usage," is a treatment to manage iron overload and not a complication associated with Thalassemia major.

Option C, "Immunosuppressive therapy," is not typically used to manage Thalassemia major and is not a long-term complication but rather a potential treatment for certain cases of thalassemia.

Option D. Hemochromatosis/Hemosiderosis

Thalassemia major is a genetic disorder that results in the body's inability to produce enough hemoglobin, leading to severe anemia.

To manage this condition, frequent blood transfusions are required, which can lead to iron overload in the body. Excess iron gets deposited in various organs and tissues, causing damage.

Hemochromatosis or hemosiderosis is a condition characterized by the accumulation of iron in organs like the liver, heart, and endocrine glands, which can result from repeated blood transfusions.

The complications associated with iron overload include liver damage, heart problems, diabetes, and more. Treatment with iron chelating agents like deferoxamine is often necessary to remove excess iron from the body.

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Correct Answer is ["A","C","E"]

Explanation

A. Fatigue: Children with ALL often experience fatigue and weakness due to decreased red blood cell and platelet production as a result of bone marrow involvement by leukemia cells.

C. Pallor: Pallor, or paleness, is a common finding in children with ALL because of anemia (reduced red blood cell count).

E. Multiple bruises: Children with ALL may have an increased tendency to bruise and bleed due to low platelet counts, making them susceptible to easy bruising and petechiae.

The other options, B (Generalized edema) and D (Jaundice), are not typical clinical findings associated with ALL. Generalized edema is not a common symptom, and jaundice (yellowing of the skin and eyes) is more commonly associated with liver conditions, not leukemia.

A. Diabetes Insipidus B. Acromegaly C. Addisons disease D. Syndrome of inappropriate Antiduretic Hormone

Correct Answer is D

Explanation

A. Diabetes Insipidus is associated with reduced ADH levels, leading to excessive urination and dehydration, not hyponatremia.

B. Acromegaly results from excessive growth hormone (not ADH) secretion, causing abnormal growth of tissues and bones.

C. Addison's disease involves the adrenal glands and the insufficient production of cortisol and aldosterone, not ADH-related hyponatremia.

D. Syndrome of Inappropriate Antidiuretic Hormone (SIADH).

SIADH is a disorder characterized by the excessive release of antidiuretic hormone (ADH) from the posterior pituitary gland, leading to increased water reabsorption by the kidneys. This results in diluted blood and hyponatremia (low sodium levels) due to the retention of water. Patients with SIADH often experience fluid overload and related symptoms.

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A long-term complication sees in Thalassemia major are associated to which of the following?

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Naxlex Comprehensive Predictor Exams

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Correct Answer is ["A","C","E"]

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Correct Answer is D

Explanation

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