A nurse is caring for a client who has Cushing’s syndrome. Which of the following clinical manifestations should the nurse expect to observe? (Select all that apply.)

Choice A: Bradycardia. This is not a manifestation of gastrointestinal perforation, but rather a sign of vagal stimulation, which can occur in response to gastric distension, vomiting, or suctioning. Vagal stimulation can slow down the heart rate and lower the blood pressure.

Choice B: Hyperactive bowel sounds. This is not a manifestation of gastrointestinal perforation, but rather a sign of increased intestinal motility, which can occur in response to inflammation, infection, or irritation of the gastrointestinal tract. Hyperactive bowel sounds are loud, high-pitched, and frequent.

Choice C: Report of epigastric fullness. This is not a manifestation of gastrointestinal perforation, but rather a sign of delayed gastric emptying, which can occur in response to gastric outlet obstruction, gastroparesis, or pyloric stenosis. Epigastric fullness is a feeling of pressure or discomfort in the upper abdomen after eating.

Choice D: Severe upper abdominal pain. This is a manifestation of gastrointestinal perforation, which is a life-threatening complication of peptic ulcer disease. Peptic ulcer disease is a condition that causes erosion and ulceration of the mucosal lining of the stomach or duodenum. If the ulcer penetrates through the wall of the gastrointestinal tract, it can cause perforation, which is a hole that allows gastric contents to leak into the peritoneal cavity. This can cause peritonitis, which is an inflammation and infection of the peritoneum. Peritonitis can cause severe upper abdominal pain, which may radiate to the shoulder or back. The pain may be sudden, sharp, and constant.

Choice A: Palpitations. This is not a finding that the nurse should expect in a client who has a new diagnosis of hypothyroidism, but rather a sign of hyperthyroidism, which is a condition that occurs when the thyroid gland produces too much thyroid hormone. Hyperthyroidism can cause palpitations due to increased cardiac output and heart rate.

Choice B: Weight gain. This is a finding that the nurse should expect in a client who has a new diagnosis of hypothyroidism, which is a condition that occurs when the thyroid gland does not produce enough thyroid hormone. The thyroid hormone regulates the metabolism of carbohydrates, proteins, and fats, and affects energy expenditure and body temperature. Hypothyroidism can cause weight gain due to decreased metabolic rate and increased fluid retention.

Choice C: Diaphoresis. This is not a finding that the nurse should expect in a client who has a new diagnosis of hypothyroidism, but rather a sign of hyperthyroidism. Hyperthyroidism can cause diaphoresis due to increased heat production and vasodilation.

Choice D: Protruding eyeballs. This is not a finding that the nurse should expect in a client who has a new diagnosis of hypothyroidism, but rather a sign of Graves’ disease, which is an autoimmune disorder that causes hyperthyroidism. Graves’ disease can cause protruding eyeballs due to inflammation and edema of the orbital tissues and muscles.