A nurse is caring for a client who has multiple sclerosis and is experiencing progressive multifocal leukoencephalopathy (PML). Which of the following medications should the nurse recognize is associated with the development of PML?

Choice A Reason:

Sedatives do not impact the risk of obstructive sleep apnea: This statement is incorrect. Sedatives, particularly those that cause muscle relaxation or depress the central nervous system, can exacerbate obstructive sleep apnea by further relaxing the muscles of the upper airway, leading to increased airway collapse during sleep.

Choice B Reason:

CPAP compliance enhances quality of sleep is correct. Continuous positive airway pressure (CPAP) therapy is a common treatment for obstructive sleep apnea. Compliance with CPAP therapy, meaning consistent and proper use of the CPAP device during sleep, is essential for effectively managing sleep apnea and improving sleep quality.

Choice C Reason:

Alcohol does not affect the risk of obstructive sleep apnea. This statement is incorrect. Alcohol consumption can worsen obstructive sleep apnea by promoting muscle relaxation in the upper airway, leading to increased airway collapse and more frequent episodes of apnea during sleep.

Choice D Reason:

Obesity increases the risk of obstructive sleep apnea. This statement is correct. Obesity is a significant risk factor for obstructive sleep apnea. Excess fat tissue around the neck can increase the likelihood of airway obstruction during sleep, contributing to the development or worsening of sleep apnea.

Choice E Reason:

Positional therapy enhances client comfort is correct. Positional therapy involves strategies to encourage sleeping in positions that minimize the severity of obstructive sleep apnea, particularly for individuals with positional OSA (where apnea events are primarily or significantly worse when sleeping in specific positions, such as supine). This statement is correct.

Choice F Reason:

Smoking increases the risk of obstructive sleep apnea: This statement is correct. Smoking can increase the risk of obstructive sleep apnea due to its effects on upper airway inflammation and respiratory function. Smoking cessation can be beneficial in managing sleep apnea and improving overall health.

Choice A Reason:

COPD is a chronic lung condition characterized by airflow limitation that is not fully reversible. Individuals with COPD often have underlying structural lung changes, such as emphysematous bullae or blebs. These areas of weakened lung tissue are prone to rupture, leading to the development of pneumothorax. Additionally, the chronic inflammation and damage to the airways and lung parenchyma in COPD contribute to the development of pneumothorax.

Choice B Reason:

Sarcoidosis is incorrect. Sarcoidosis is a granulomatous disease that primarily affects the lungs and lymph nodes. While it can cause lung damage and lead to pneumothorax, it is less common than COPD as a comorbidity associated with SSP.

Choice C Reason:

Lung cancer is incorrect. Lung cancer can lead to pneumothorax, especially if the tumor erodes into the pleural space. However, SSP is more commonly associated with underlying lung diseases like COPD rather than lung cancer.

Choice D Reason:

Cystic fibrosis is incorrect. Cystic fibrosis is a genetic disorder characterized by abnormal mucus production and impaired clearance in various organs, including the lungs. While individuals with cystic fibrosis are at increased risk of pneumothorax due to underlying lung disease, SSP is less commonly seen in this population compared to COPD.