A nurse is educating a client about the two main types of antipsychotics. Select all that apply:
First-generation antipsychotics have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors.
Second-generation antipsychotics have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors.
First-generation antipsychotics have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors.
Second-generation antipsychotics have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors.
Both first-generation and second-generation antipsychotics have a high affinity for both dopamine D2 and serotonin 5-HT2A receptors.
Correct Answer : B
Second-generation antipsychotics have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors. This means that they block less dopamine and more serotonin in the brain, which reduces the risk of extrapyramidal side effects and improves negative symptoms of schizophrenia.
Choice A is wrong because first-generation antipsychotics have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors. This means that they block more dopamine and less serotonin in the brain, which increases the risk of extrapyramidal side effects and does not improve negative symptoms of schizophrenia.
Choice C is wrong because it is the opposite of choice A. First-generation antipsychotics do not have a low affinity for dopamine D2 receptors and a high affinity for serotonin 5-HT2A receptors.
Choice D is wrong because it is the opposite of choice B. Second-generation antipsychotics do not have a high affinity for dopamine D2 receptors and a low affinity for serotonin 5-HT2A receptors.
Choice E is wrong because both first-generation and second-generation antipsychotics do not have a high affinity for both dopamine D2 and serotonin 5-HT2A receptors. They have different affinities for these receptors, which account for their different effects and side effects.
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Related Questions
Correct Answer is D
Explanation
Sedation and weight gain are common side effects of atypical antipsychotic medications.These medications act on both dopamine and serotonin receptors in the brain and may also have some antidepressant effects.
Choice A is wrong because weight loss and hypotension are not typical side effects of atypical antipsychotics.In fact, weight gain is more likely to occur.
Choice B is wrong because hyperactivity and insomnia are not typical side effects of atypical antipsychotics.These medications may cause difficulty sleeping and extreme tiredness.
Choice C is wrong because blurred vision and urinary retention are not typical side effects of atypical antipsychotics.These medications may cause dry mouth and constipation.
Other possible side effects of atypical antipsychotics include dizziness, seizures, allergic reactions, heart problems, and high prolactin levels.Some atypical antipsychotics may also cause extrapyramidal symptoms, such as muscle spasms, restlessness, tremors, or abnormal movements.
These are more common with typical antipsychotics.
Atypical antipsychotics are used to treat various mental health conditions, such as schizophrenia, bipolar disorder, OCD, and treatment-resistant mania.They may also be prescribed off-label for other conditions, such as Tourette’s syndrome.
Correct Answer is A
Explanation
Drowsiness is a common adverse effect of antipsychotics, especially in the first few weeks of treatment.Antipsychotics block dopamine receptors in the brain, which can cause sedation and fatigue.
Choice B is wrong because antipsychotics usually increase appetite, not decrease it.This can lead to weight gain and metabolic problems.
Choice C is wrong because antipsychotics do not cause increased energy and restlessness.These symptoms may indicate a manic episode or akathisia, which is a movement disorder that can be caused by antipsychotics.
Choice D is wrong because antipsychotics do not directly improve mood. They are used to treat psychotic symptoms such as hallucinations and delusions.Mood stabilizers or antidepressants may be needed to treat mood disorders.
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