A nurse is educating a client who has a respiratory infection and a new prescription for azithromycin (Zithromax).
Which of the following instructions should the nurse include? (Select all that apply).

Take the medication with or without food

Report any signs of jaundice or dark urine

Avoid drinking grapefruit juice while taking this medication

Complete the full course of therapy as prescribed

Store the medication in a cool and dry place.

Answer and Explanation

Correct Answer : B,C,D

Choice A is wrong because azithromycin (Zithromax) should be taken with food to prevent stomach upset.

Choice B is correct because azithromycin can cause liver damage and the client should report any signs of jaundice or dark urine as they may indicate liver problems.

Choice C is correct because azithromycin can interact with grapefruit juice and increase the risk of side effects such as nausea, vomiting, diarrhea, headache and QT interval prolongation.

Choice D is correct because the client should complete the full course of therapy as prescribed to prevent bacterial resistance and recurrence of infection.

Choice E is wrong because azithromycin should be stored in a refrigerator and discarded after 10 days if it is in a liquid form.

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Correct Answer is E

Explanation

Gentamicin is an example of a concentration-dependent antimicrobial, which means that it achieves increasing bacterial kill with increasing levels of drug.The peak concentration and the area under the concentration curve (AUC) determine the efficacy of these antibiotics.Other examples of concentration-dependent antimicrobials include fluoroquinolones, daptomycin, aminoglycosides, and amphotericin

Choice A is wrong because ciprofloxacin is a fluoroquinolone, which is also a concentration-dependent antimicrobial.

Choice B is wrong because imipenem is a carbapenem, which is a type of beta-lactam antibiotic.Beta-lactams are time-dependent antimicrobials, which means that their bactericidal activity depends on the duration of the effective concentration.

Choice C is wrong because penicillin V is another type of beta-lactam antibiotic, which is also a time-dependent antimicrobial.

Choice D is wrong because metronidazole is a bactericidal agent that has both time- and concentration-dependent properties.However, it is not classified as a concentration-dependent antimicrobial according to the AMEG categorization of antibiotics in the European Union.

A. Tinnitus B. Vertigo C. Hearing loss D. All of the above.

Correct Answer is D

Explanation

Vancomycin is an antibiotic that can cause ototoxicity, which is damage to the inner ear due to exposure to certain drugs.Ototoxicity can manifest as tinnitus (ringing in the ears), vertigo (dizziness), and hearing loss.Vancomycin ototoxicity is usually related to high serum levels of the drug and is more likely to occur in patients with renal impairment.Vancomycin can also potentiate the ototoxicity of other drugs, such as aminoglycosides.

Choice A is wrong because tinnitus is a possible manifestation of ototoxicity.

Choice B is wrong because vertigo is a possible manifestation of ototoxicity.

Choice C is wrong because hearing loss is a possible manifestation of ototoxicity.

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A nurse is educating a client who has a respiratory infection and a new prescription for azithromycin (Zithromax). Which of the following instructions should the nurse include? (Select all that apply).

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

Which antibiotics are classified as concentration-dependent antimicrobials?

Correct Answer is E

Explanation

A nurse is caring for a client who has a severe infection and is receiving vancomycin (Vancocin). The nurse should monitor the client for which of the following manifestations of ototoxicity?

Correct Answer is D

Explanation

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A nurse is caring for a client who has tuberculosis and is prescribed rifampin, an antitubercular drug. The nurse should instruct the client about which potential side effect of rifampin?

A nurse is caring for a client who is receiving gentamicin, an aminoglycoside antibiotic, for a severe infection. The nurse should monitor the client for which adverse effects of this drug? (Select all that apply.)

A nurse is educating a client who has a respiratory infection and a new prescription for azithromycin (Zithromax).
Which of the following instructions should the nurse include? (Select all that apply).