A nurse is reviewing the culture and sensitivity report of a patient who has a wound infection caused by Staphylococcus aureus.
The report indicates that the organism is sensitive to several antibiotics, including oxacillin, erythromycin, and clindamycin. Which antibiotic should be chosen for this patient? (Select all that apply.).

The client should avoid sexual intercourse until treatment is completed.This is because trichomoniasis is a sexually transmitted infection that can be passed between partners during penile-vaginal sex or through transmission of infected vaginal fluids or fomites among women who have sex with women. Therefore, abstaining from sex until both partners are cured can prevent reinfection and transmission.

Choice A is wrong because taking the medication with an antacid can reduce its absorption and effectiveness.Tinidazole should be taken with food to minimize gastrointestinal side effects.

Choice B is wrong because drinking plenty of fluids to prevent crystalluria is not relevant for tinidazole.

Crystalluria is a condition where crystals form in the urine, which can cause kidney stones or damage.This is a potential complication of some antibiotics, such as sulfonamides, but not tinidazole.

Choice D is wrong because chewing the tablets thoroughly before swallowing is not necessary for tinidazole.Tinidazole tablets are film-coated and can be swallowed whole with water.

Chewing the tablets may alter their release and absorption, and may also cause a bitter aftertaste.

A microbe acquires antibiotic resistance by transferring DNA coding to other bacteria or by spontaneous mutation in the microbial genome.

These genetic changes allow the microbe to survive the effects of the antibiotic and pass on the resistance to its offspring.

ChoiceAis wrong because the host does not develop medication resistance, but the microbe does.

ChoiceBis wrong because the minimum bactericidal concentration (MBC) is the lowest concentration of an antibiotic needed to kill 99.9% of bacteria, not a mechanism of resistance.

ChoiceCis wrong because incorrect dosing does not cause ribosome mutations, but may promote the emergence of drug-resistant microbes by exposing them to suboptimal levels of the antibiotic.