A nurse is reviewing the culture and sensitivity report of a patient who has a wound infection caused by Staphylococcus aureus.
The report indicates that the organism is sensitive to several antibiotics, including oxacillin, erythromycin, and clindamycin. Which antibiotic should be chosen for this patient? (Select all that apply.).

Ceftriaxone belongs to the third-generation of cephalosporins.Third-generation cephalosporins have greater activity than the second-generation cephalosporins against certain gram-negative bacteria, such as Streptococcus pneumoniae.They are also more resistant to beta-lactamases, enzymes that can inactivate some cephalosporins.

Choice A is wrong because first-generation cephalosporins have less activity against gram-negative bacteria and are more susceptible to beta-lactamases.

Choice B is wrong because second-generation cephalosporins have less activity against Streptococcus pneumoniae than third-generation cephalosporins, and are also less resistant to beta-lactamases.

Choice D is wrong because fourth-generation cephalosporins have a broader spectrum of activity against gram-negative bacteria, including some that are resistant to third-generation cephalosporins, but they are not more effective against Streptococcus pneumoniae.

Vancomycin is an antibiotic that can cause ototoxicity, which is damage to the inner ear due to exposure to certain drugs.Ototoxicity can manifest as tinnitus (ringing in the ears), vertigo (dizziness), and hearing loss.Vancomycin ototoxicity is usually related to high serum levels of the drug and is more likely to occur in patients with renal impairment.Vancomycin can also potentiate the ototoxicity of other drugs, such as aminoglycosides.

Choice A is wrong because tinnitus is a possible manifestation of ototoxicity.

Choice B is wrong because vertigo is a possible manifestation of ototoxicity.

Choice C is wrong because hearing loss is a possible manifestation of ototoxicity.