A nurse is reviewing a client's peak and trough levels of gentamicin. The peak should be 6 to 8 mcg/mL and the trough should be 0.5 to 1 mcg/mL. The client's peak is10 mcg/mL and his trough is 2.3 mcg/mL. Which of the following clinical manifestations should the nurse expect with these findings? (Select all that apply.)

A. Diarrhea is a common side effect associated with ondansetron, which is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery.

B. Ondansetron can potentially cause changes in glucose metabolism, leading to hyperglycemia, especially in clients with diabetes mellitus. Monitoring blood glucose levels is essential during ondansetron administration, particularly in clients who are already predisposed to hyperglycemia.

D. Headache is a potential adverse effect of ondansetron. It is listed as a common side effect and should be monitored, especially in older adults who may be more sensitive to medication effects.

C. Ondansetron can affect the QT interval rather than the PR interval. It may cause QT interval prolongation, which can predispose the client to arrhythmias

D. Blurred vision is a known adverse effect of metoclopramide. It can occur due to its effects on the central nervous system, including potential effects on visual processing. Patients should be informed about this potential side effect, and vision should be monitored periodically.

A. Metoclopramide can cause drowsiness or sedation, especially at higher doses or in susceptible individuals. Monitoring for sedation is important to ensure patient safety and adjust dosing as needed.

B. Urinary retention: Although less common, metoclopramide has been associated with urinary retention. Patients should be monitored for signs and symptoms of urinary difficulty or retention, especially if they have pre-existing urinary issues.

C. Hypertension: Metoclopramide can occasionally lead to an increase in blood pressure, particularly in patients who are predisposed to hypertension or have other cardiovascular risk factors. Blood pressure monitoring is important during treatment.