A nurse is reviewing a client's peak and trough levels of gentamicin. The peak should be 6 to 8 mcg/mL and the trough should be 0.5 to 1 mcg/mL. The client's peak is10 mcg/mL and his trough is 2.3 mcg/mL. Which of the following clinical manifestations should the nurse expect with these findings? (Select all that apply.)

B. Dextrose 10% in water is a solution that contains a high concentration of glucose (dextrose). Infusing D10W can lead to an increase in blood glucose levels, especially if the client's body cannot metabolize the glucose effectively (e.g., in diabetic patients or those with impaired glucose tolerance).

A. Dextrose 10% in water does not contain calcium. Hypercalcemia refers to elevated calcium levels in the blood, which can occur due to various causes such as hyperparathyroidism or excessive vitamin D intake, but not from D10W infusion.

C. Dextrose 10% in water is not used to treat hypovolemia (low blood volume). It is a solution primarily used to provide calories and prevent ketosis rather than to expand circulating blood volume.

D. Dextrose 10% in water does not contain potassium. Hypokalemia (low potassium levels) can occur due to various reasons such as diuretic use, gastrointestinal losses, or inadequate intake, but it is not directly related to D10W infusion.

D. Numbness and tingling of the hands and feet can indicate peripheral neuropathy, a known adverse effect of nitrofurantoin. It's essential for the nurse to recognize and communicate the potential seriousness of these symptoms to the client.

A. Numbness and tingling are not typically related to hydration status. While adequate hydration is important for overall health, it does not directly prevent numbness and tingling caused by medication side effects.

B. Symptoms like urinary frequency, burning, and dysuria are common symptoms of a urinary tract infection, not indicators of the medication working.

C Numbness and tingling of the hands and feet can be indicative of peripheral neuropathy, which is a potential adverse reaction to nitrofurantoin. While not all cases are severe, it's crucial to assess the severity and duration of these symptoms and notify the healthcare provider.