A nurse is teaching a client who has a new prescription for total parenteral nutrition (TPN). Which of the following information should the nurse include in the teaching?

B) Melena: Melena refers to black, tarry stools and is indicative of upper gastrointestinal bleeding. Warfarin is an anticoagulant medication that works by inhibiting the synthesis of vitamin K-dependent clotting factors, thereby prolonging the time it takes for blood to clot. While anticoagulation is intended to prevent thrombosis, it also increases the risk of bleeding, including gastrointestinal bleeding. Melena is a concerning sign of significant bleeding and requires prompt medical attention. The nurse should prioritize reporting melena to the provider to facilitate further evaluation and management, which may include adjusting the warfarin dosage or investigating the underlying cause of the bleeding.

A) Hair loss: Hair loss, or alopecia, is a known side effect of warfarin but is generally not considered a priority finding compared to signs of active bleeding. While hair loss can be distressing for clients, it is typically not life-threatening and may resolve spontaneously or with discontinuation of the medication.

C) Abdominal cramping: Abdominal cramping can occur for various reasons, including gastrointestinal upset or other gastrointestinal issues, but it is not typically associated with warfarin use. While the nurse should assess and address the client's abdominal cramping, it is not as urgent as reporting signs of active bleeding such as melena.

D) Fever: Fever may indicate the presence of an infection or inflammatory process but is not directly related to warfarin therapy. However, if the fever is accompanied by signs of bleeding or other concerning symptoms, it should be reported to the provider for further evaluation. Nonetheless, in the absence of other significant symptoms, fever alone may not be as urgent as reporting melena, which suggests active bleeding.

A) The client has an increased creatinine level: While an increased creatinine level may indicate renal impairment, it is not specific to a vancomycin infusion reaction. Elevated creatinine levels may occur due to various factors, including underlying kidney disease or dehydration.

B) The client is experiencing hypotension: This is the correct answer. Hypotension, or low blood pressure, can be a manifestation of a vancomycin infusion reaction. Vancomycin infusion reactions may include anaphylaxis or anaphylactoid reactions, which can lead to systemic vasodilation and subsequent hypotension.

C) The client's IV site is red and edematous: Redness ’nd edema at the IV site may indicate phlebitis or infiltration, which are local complications rather than systemic reactions to vancomycin infusion.

D) The client reports ringing in their ears: Ringing in the ears, also known as tinnitus, is a potential side effect of vancomycin, particularly with high doses or prolonged use. However, it is not specific to a vancomycin infusion reaction and may occur independently of the infusion process.