A nurse is teaching a nursing student what is meant by "generations" of cephalosporins. Which statement by the student indicates an understanding of the teaching?
"Cephalosporins are assigned to generations based on their relative costs to administer."
"Later generations of cephalosporins have lower resistance to destruction by beta-lactamases."
"Cephalosporins have increased activity against gram-negative bacteria with each new generation."
"First-generation cephalosporins have better penetration of the cerebrospinal fluid."
The Correct Answer is C
A. "Cephalosporins are assigned to generations based on their relative costs to administer."
This statement is incorrect. The classification of cephalosporins into generations is based on their antimicrobial spectrum and activity against specific bacteria, not their cost.
B. "Later generations of cephalosporins have lower resistance to destruction by beta-lactamases."
This statement is not accurate. In fact, later generations of cephalosporins have increased resistance to destruction by beta-lactamases, which are enzymes produced by bacteria that can break down certain antibiotics.
C. "Cephalosporins have increased activity against gram-negative bacteria with each new generation."
This statement is correct. Cephalosporins are grouped into generations (first to fifth) based on their antibacterial spectrum. As the generations progress, there is an increase in activity against gram-negative bacteria, among other improvements in their spectrum.
D. "First-generation cephalosporins have better penetration of the cerebrospinal fluid."
This statement is generally true. First-generation cephalosporins have better penetration into the cerebrospinal fluid, making them useful for treating certain central nervous system infections.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
A. Discoloration of teeth: Tetracycline antibiotics can bind with calcium ions in teeth, leading to the development of yellow-gray-brown stains. This effect is particularly significant in developing teeth in children below the age of 8 and can result in permanent discoloration.
B. Anabolic change: This term doesn't specifically relate to the side effects of tetracycline. "Anabolic" generally refers to processes in the body that build up complex molecules from simpler ones. There's no direct connection between tetracycline and anabolic changes.
C. Cartilage damage: Tetracyclines, especially in high doses or with prolonged use, have been associated with potential adverse effects on cartilage. This is more relevant in individuals whose bones and cartilage are still growing, such as children. It can interfere with skeletal development.
D. Suppression of growth: Long-term use of tetracycline in children can interfere with bone growth and development. It can suppress the growth of bones and affect overall height. This is a significant concern when considering the use of tetracycline in pediatric patients.
Correct Answer is B
Explanation
A. Wear high-top shoes to avoid tendon rupture:
This statement is incorrect. Tendon rupture is a known side effect of fluoroquinolone antibiotics like ciprofloxacin, especially in certain populations. However, wearing high-top shoes does not prevent this. Patients should be educated about the signs of tendon pain, swelling, or inflammation and should be advised to stop the medication and contact their healthcare provider if they experience such symptoms.
B. Use a barrier method of birth control (condoms) during antibiotic use:
This statement is partially correct. Antibiotics like ciprofloxacin do not interfere with the efficacy of hormonal birth control methods like pills, patches, or injections. However, it's advisable to use a barrier method like condoms as an additional form of contraception while taking antibiotics. This is to prevent potential interactions and ensure maximum contraceptive effectiveness.
C. Do not use any bronchodilator inhalers while taking the drug:
This statement is incorrect. Ciprofloxacin does not interact negatively with bronchodilator inhalers. Patients can continue using their prescribed inhalers as directed by their healthcare provider, especially if they are being used for conditions like asthma or chronic obstructive pulmonary disease (COPD).
D. Stop the medication as soon as you feel better:
This statement is incorrect. It's crucial for patients to complete the entire course of antibiotics as prescribed, even if they start feeling better before the course is finished. Stopping antibiotics prematurely can lead to incomplete eradication of the infection, potentially allowing the bacteria to develop resistance and cause a recurrence of the illness.
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