A patient who is HIV-positive has been receiving medication therapy that includes zidovudine.
The prescriber has decided to stop the zidovudine due to its dose-limiting adverse effect.
Which of these conditions is the dose-limiting adverse effect of zidovudine therapy?
Bone marrow suppression
Retinitis
Renal toxicity
Hepatotoxicity
The Correct Answer is A
Choice A rationale:
Zidovudine, also known as AZT, is a medication used for the treatment of human immunodeficiency virus (HIV) infection. One of the major dose-limiting toxic effects of Zidovudine is hematologic toxicity, which manifests clinically as anemia, neutropenia, and sometimes as platelet deficits with onset after several weeks of treatment. This hematologic toxicity is essentially a form of bone marrow suppression. Therefore, bone marrow suppression is the dose-limiting adverse effect of zidovudine therapy.
Choice B rationale:
Retinitis is not a known dose-limiting adverse effect of zidovudine. While zidovudine has a range of side effects, retinitis is not commonly associated with its use.
Choice C rationale:
Renal toxicity is not a known dose-limiting adverse effect of zidovudine. While zidovudine can have various side effects, renal toxicity is not typically one of them.
Choice D rationale:
Hepatotoxicity is not the dose-limiting adverse effect of zidovudine. While severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of zidovudine, it is not considered the dose-limiting adverse effect. The dose-limiting adverse effect is more specifically related to hematologic toxicity, which includes bone marrow suppression.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A rationale:
The statement “The intravenous medication will have delayed absorption into the body’s tissues” is incorrect. Intravenous (IV) therapy is administering fluids directly into a vein. It benefits treatment by enabling water, medication, blood, or nutrients to access the body faster through the circulatory system. This bypasses the gastric system so the body can take on more fluids quickly. Therefore, the absorption of intravenous medication into the body’s tissues is not delayed but rather immediate.
Choice B rationale:
The statement “The action of the medication will begin sooner when given intravenously” is correct. Administering a medication intravenously eliminates the process of drug absorption and breakdown by directly depositing it into the blood. This results in the immediate elevation of serum levels and high concentration in vital organs, such as the heart, brain, and kidneys. Therefore, the action of the medication begins sooner when given intravenously.
Choice C rationale:
The statement “The medication will cause fewer adverse effects when given intravenously” is not necessarily true. While some medications might cause fewer adverse effects when given intravenously, this is not a general rule for all medications. The adverse effects of a medication depend on various factors including the type of medication, the dose, the patient’s health condition, and more.
Choice D rationale:
The statement “There is a lower chance of allergic reactions when drugs are given intravenously” is not necessarily true. The chance of allergic reactions depends on various factors including the type of drug, the patient’s immune response, previous exposure to the drug, and more. It’s not related to the route of administration.
Correct Answer is C
Explanation
Choice A rationale:
Fluconazole Fluconazole is an antifungal medication used to treat and prevent fungal infections. It works by stopping the growth of certain types of fungus. However, it is not effective against bacterial infections such as anthrax.
Choice B rationale:
Tobramycin Tobramycin is an aminoglycoside antibiotic used to treat various types of bacterial infections, particularly Gramnegative infections. It works by stopping the growth of bacteria. However, it is not typically used to treat anthrax.
Choice C rationale:
Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic used for the treatment of a number of bacterial infections. This includes bone and joint infections, intra-abdominal infections, certain type of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. For the treatment of anthrax, ciprofloxacin is one of the antibiotics that could be used. It works by killing the anthrax or by stopping the anthrax from growing. When the anthrax can’t grow anymore, it dies.
Choice D rationale:
Vancomycin Vancomycin is an antibiotic used to treat a number of bacterial infections. It is recommended intravenously as a treatment for complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus. However, it is not typically used to treat anthrax.
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