In bipolar disorder, it is theorized that initial episodes are likely triggered by major life events that cause the brain to become overly sensitive to electrical stimulation. Successive episodes grow increasingly more autonomous due to neuronal misfiring. Which term represents this concept?
GABA deregulation
Kindling
Genetic loading
Voltage-gated channel abnormalities
The Correct Answer is B
Choice A reason: GABA deregulation refers to disruptions in inhibitory neurotransmission, which may contribute to bipolar symptoms but does not specifically explain the progressive sensitization seen with repeated episodes.
Choice B reason: Kindling describes the process by which repeated subthreshold stimulation of neurons eventually leads to spontaneous, autonomous activity. In bipolar disorder, initial episodes are triggered by stressors, but later episodes may occur with decreasing external provocation, reflecting the kindling phenomenon.
Choice C reason: Genetic loading refers to inherited susceptibility to bipolar disorder but does not account for the progressive, self-propagating nature of episodes.
Choice D reason: Voltage-gated channel abnormalities may play a role in neuronal excitability but do not specifically describe the phenomenon of progressive autonomy in episode recurrence seen in bipolar disorder.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
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Correct Answer is A
Explanation
Choice A reason: Avoiding weight-bearing activity is contraindicated in osteoporosis management. Regular weight-bearing exercises strengthen bones and improve balance, reducing fracture risk.
Choice B reason: Yoga improves balance, flexibility, and strength, contributing positively to osteoporosis management and fall prevention.
Choice C reason: Smoking and excessive alcohol consumption negatively affect bone density; cessation is an important preventive measure.
Choice D reason: Adequate calcium intake supports bone health and is essential in osteoporosis management, along with vitamin D and exercise.
Correct Answer is B
Explanation
Choice A reason: Intra-articular glucocorticoids may be used for flare management in specific joints but are not first-line systemic therapy for mild psoriatic arthritis.
Choice B reason: NSAIDs are first-line therapy for mild psoriatic arthritis, providing anti-inflammatory and analgesic effects without the risks associated with immunosuppressants.
Choice C reason: Opioids are not recommended for arthritis management due to risk of dependence and do not address inflammation.
Choice D reason: Pregabalin is indicated for neuropathic pain, not inflammatory arthritis, and is not appropriate for first-line treatment of psoriatic arthritis.
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