The barbiturate phenobarbital is prescribed for a patient with epilepsy. While assessing the patient's current medications, the nurse recognizes that interactions may occur with which drugs? (Select all that apply.)
Oral contraceptives
Antihistamines
Warfarin
Opioids
Diuretics
Correct Answer : A,D,E
A. Oral contraceptives: Phenobarbital can decrease the effectiveness of oral contraceptives, increasing the risk of contraceptive failure and unintended pregnancy.
B. Antihistamines: While phenobarbital can induce hepatic enzymes, leading to increased
metabolism of some antihistamines, this interaction is less clinically significant compared to the interactions with oral contraceptives, opioids, and diuretics.
C. Warfarin: Phenobarbital can induce the metabolism of warfarin, potentially reducing its anticoagulant effects and necessitating closer monitoring of international normalized ratio (INR) levels.
D. Opioids: Phenobarbital can increase the metabolism of opioids, leading to reduced analgesic effects and potentially causing inadequate pain control.
E. Diuretics: Phenobarbital can accelerate the metabolism of diuretics, potentially reducing their efficacy and necessitating adjustments in dosage or monitoring of electrolyte levels.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A. Carbamazepine is an anticonvulsant medication used to treat seizures and certain mood disorders. It is not typically used in the treatment of Parkinson's disease.
B. Piperacillin/tazobactam is an antibiotic combination used to treat bacterial infections. It is not used in the treatment of Parkinson's disease.
C. Levothyroxine is a synthetic thyroid hormone used to treat hypothyroidism. It is not used in the treatment of Parkinson's disease.
D. Levodopa/carbidopa is a medication commonly used in the treatment of Parkinson's disease to manage motor symptoms such as tremor, rigidity, and bradykinesia. The nurse should provide
thorough education to the client regarding the indication, dosage, administration, potential side effects, and precautions associated with levodopa/carbidopa therapy.
Correct Answer is B
Explanation
A. Egg salad sandwich: Eggs are generally considered safe to consume with MAOIs. There are no significant interactions between egg salad and MAOIs.
B. Pepperoni pizza: Pepperoni contains high levels of tyramine, which can cause a hypertensive crisis when consumed with MAOIs. Therefore, pepperoni pizza should be avoided by patients
taking MAOIs.
C. Pancakes and maple syrup: Pancakes and maple syrup are generally safe choices with MAOIs, as they do not contain high levels of tyramine.
D. Fried eggs over-easy: Like egg salad, fried eggs are generally considered safe to consume with MAOIs. There are no significant interactions between fried eggs and MAOIs.
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