The nurse is caring for several clients with osteoporosis. For which client would bisphosphonates not be a good option?
Client with diabetes who has a serum creatinine of 0.8 mg/dL (61 mcmol/L).
Client who recently fell and has vertebral compression fractures.
Hypertensive client who takes calcium channel blockers.
Client with a spinal cord injury who cannot tolerate sitting up.
The Correct Answer is D
Choice A reason: Bisphosphonates are generally safe for clients with diabetes and normal renal function (serum creatinine 0.8 mg/dL is within normal range, indicating adequate kidney function). These drugs inhibit osteoclast activity, reducing bone resorption, and are not contraindicated in diabetes unless renal impairment is present, which is not the case here.
Choice B reason: Vertebral compression fractures are a common complication of osteoporosis. Bisphosphonates are often prescribed to strengthen bones and prevent further fractures by inhibiting bone resorption. Recent fractures do not contraindicate their use; in fact, they are indicated to improve bone density and reduce future fracture risk.
Choice C reason: Calcium channel blockers, used for hypertension, do not interact significantly with bisphosphonates. These drugs work on different systems—bisphosphonates on bone metabolism and calcium channel blockers on vascular smooth muscle. There is no evidence suggesting this combination poses a risk, making bisphosphonates appropriate for this client.
Choice D reason: Bisphosphonates, especially oral ones, require patients to sit upright for 30–60 minutes post-dose to prevent esophageal irritation and ensure proper absorption. A client with a spinal cord injury unable to tolerate sitting up cannot comply with this requirement, increasing the risk of esophageal damage, making bisphosphonates a poor choice.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["B","C","E"]
Explanation
Choice A reason: Anorexia is not a hallmark late sign of RA. It may occur early due to systemic inflammation but is less specific in late stages, where joint damage and systemic complications like Felty syndrome dominate.
Choice B reason: Felty syndrome, a late RA complication, involves neutropenia, splenomegaly, and recurrent infections due to chronic immune activation. It occurs in long-standing RA, reflecting severe disease progression, making it a key late finding.
Choice C reason: Joint deformity (e.g., swan-neck, boutonniere) is a classic late RA sign due to chronic synovial inflammation eroding cartilage and bone, causing joint instability and deformation, significantly impacting function in advanced disease.
Choice D reason: Low-grade fever is an early RA symptom due to systemic inflammation but typically diminishes in late stages. Chronic joint damage and systemic complications are more prominent, making fever less characteristic of late RA.
Choice E reason: Weight loss is a late RA sign due to chronic inflammation, increased metabolic demand, and cytokine activity (e.g., TNF-alpha). It reflects disease severity and systemic impact, common in advanced RA with joint destruction.
Correct Answer is C
Explanation
Choice A reason: Stress fractures result from repetitive microtrauma, common in athletes, not typically associated with abuse. In children, they occur from overuse (e.g., sports), not acute trauma, making them less suspicious for non-accidental injury compared to other fracture types.
Choice B reason: Compound fractures, where bone pierces the skin, result from high-impact trauma (e.g., falls). While possible in abuse, they are less specific, as they occur in accidents, making them less indicative of non-accidental injury than spiral fractures.
Choice C reason: Spiral fractures occur from twisting forces, often seen in abuse when a limb is forcefully twisted (e.g., by an adult). In children, whose bones are flexible, spiral fractures suggest significant force, raising suspicion of non-accidental trauma.
Choice D reason: Greenstick fractures, where the bone bends and partially breaks, are common in children due to pliable bones. They occur in accidents or minor trauma, making them less specific to abuse compared to spiral fractures’ association with twisting mechanisms.
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