The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?
Proton pump inhibitors
Calcium channel blockers
Loop diuretics
Phenytoin
The Correct Answer is C
Choice A rationale:
Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related disorders, often over the long term, which raises the potential for clinically significant drug interactions in patients receiving concomitant medications.
However, there is no specific mention of a significant interaction between PPIs and aminoglycosides.
Choice B rationale:
Aminoglycoside antibiotics and calcium channel blockers can interact at the neuromuscular junctions. This interaction is of clinical significance because when these agents are given concurrently during the perioperative period they may lead to respiratory depression or prolonged apnea. However, this is not directly related to the therapeutic effect of aminoglycosides, but rather a side effect of their combined use.
Choice C rationale:
The loop-diuretics (ethacrynic acid, furosemide, bumetamide) and aminoglycoside antibiotics (kanamycin, gentamicin, tobramycin, amikacin, etc.) are important drugs frequently used to treat seriously ill patients. Not uncommonly both types of drugs are given to the same patient exposing that patient to the risk of a hearing loss (ototoxicity)5. In addition, the risk of ototoxicity could be enhanced by the concomitant use of loop diuretics and aminoglycoside antibiotics.
Choice D rationale:
Phenytoin is a medication used to treat seizures. It has a complex pharmacokinetic profile and can interact with many other drugs. However, there is no specific mention of a significant interaction between phenytoin and aminoglycosides.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["2.5 "]
Explanation
Step 1: Identify the given values. The nurse needs to administer 2.5 mg of hydromorphone. The available amount is 5 mg/5 mL.
Step 2: Set up the calculation. We need to find out how many mL correspond to 2.5 mg. We can set up a proportion using the given values:
5 mL5 mg=x mL2.5 mg
Step 3: Solve for x. Cross-multiply and solve for x:
5 mg×x mL=2.5 mg×5 mL
Step 4: Simplify the equation:
x=5 mg.5 mg×5 mL
Step 5: Calculate the value of x:
x=2.5 mL
So, the nurse should administer 2.5 mL of the hydromorphone elixir.
Correct Answer is C
Explanation
Choice A rationale:
Administering the medications using a 3-mL medication syringe is not the best practice. While it is possible to use a 3-mL syringe for medication administration, it is not the most efficient or safest method. A larger syringe allows for easier administration and reduces the risk of creating too much pressure which could potentially damage the PEG tube.
Choice B rationale:
Applying firm pressure on the syringe’s piston to infuse the medication is not recommended. This can create too much pressure in the PEG tube and could potentially cause damage. It is generally advised to allow the medication to flow into the tube via gravity. Choice C rationale:
Flushing the tubing with 30 mL of saline after the medication has been given is the correct technique. This helps to ensure that all of the medication has been administered and also helps to keep the tube clear of any potential blockages.
Choice D rationale:
Using the barrel of the syringe, allowing the medication to flow via gravity into the tube is a common practice. However, it is not the only step in the process. It is also important to flush the tube before and after medication administration to ensure all medication is delivered and to maintain the patency of the tube.
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