The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?

Proton pump inhibitors

Calcium channel blockers

Loop diuretics

Phenytoin

Answer and Explanation

The Correct Answer is C

Choice A rationale:

Proton pump inhibitors (PPIs) are used extensively for the treatment of gastric acid-related disorders, often over the long term, which raises the potential for clinically significant drug interactions in patients receiving concomitant medications.

However, there is no specific mention of a significant interaction between PPIs and aminoglycosides.

Choice B rationale:

Aminoglycoside antibiotics and calcium channel blockers can interact at the neuromuscular junctions. This interaction is of clinical significance because when these agents are given concurrently during the perioperative period they may lead to respiratory depression or prolonged apnea. However, this is not directly related to the therapeutic effect of aminoglycosides, but rather a side effect of their combined use.

Choice C rationale:

The loop-diuretics (ethacrynic acid, furosemide, bumetamide) and aminoglycoside antibiotics (kanamycin, gentamicin, tobramycin, amikacin, etc.) are important drugs frequently used to treat seriously ill patients. Not uncommonly both types of drugs are given to the same patient exposing that patient to the risk of a hearing loss (ototoxicity)5. In addition, the risk of ototoxicity could be enhanced by the concomitant use of loop diuretics and aminoglycoside antibiotics.

Choice D rationale:

Phenytoin is a medication used to treat seizures. It has a complex pharmacokinetic profile and can interact with many other drugs. However, there is no specific mention of a significant interaction between phenytoin and aminoglycosides.

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Correct Answer is C

Explanation

Choice A rationale:

This choice is incorrect. While it’s true that antiviral drugs can be effective in treating the flu, they’re most effective when started within 48 hours of symptom onset. Starting treatment after 4 days may not provide the same benefits.

Choice B rationale:

This choice is incorrect. While a blood test can confirm the presence of the flu virus, it’s not typically necessary to diagnose the flu. Diagnosis is usually based on symptoms and the fact that the flu is widespread in the community.

Choice C rationale:

This choice is correct. Antiviral drugs are most effective when started within 2 days of symptom onset. After this time, the benefits of these drugs decrease. Therefore, starting treatment 4 days after symptoms begin may not significantly reduce the duration or severity of symptoms.

Choice D rationale:

This choice is incorrect. While it’s true that getting a flu vaccine is important, it’s not the best response in this situation. The flu vaccine won’t treat current illness. It’s designed to prevent future infections. In this case, the individual is already sick, so a booster vaccination wouldn’t be the most effective course of action.

A. It’s best to wait to see if the fever gets worse. B. You can use the aspirin, but watch for worsening symptoms. C. Acetaminophen should be used to reduce his fever, not aspirin. D. You can use aspirin but be sure to follow the instructions on the bottle.

Correct Answer is C

Explanation

Choice A rationale:

Waiting to see if the fever gets worse is not the best course of action. Fever is a symptom that the body is fighting off an infection, and it can cause discomfort in children. However, the main concern with chickenpox and fever is not the fever itself, but the risk of complications from the chickenpox. Therefore, it’s important to manage the fever for the child’s comfort but also monitor for any signs of complications.

Choice B rationale:

Aspirin should not be given to children or teenagers who have chickenpox or flu symptoms before a doctor is consulted about Reye’s Syndrome, a rare but serious illness. Reye’s syndrome is a potentially life-threatening condition that has been associated with aspirin use in children and adolescents with viral illnesses, especially chickenpox or influenza.

Choice C rationale:

Acetaminophen (Tylenol) should be used to reduce his fever, not aspirin. This is because of the risk of Reye’s syndrome associated with aspirin use in children and adolescents who have viral illnesses. Acetaminophen is a safe and effective choice for fever reduction in children.

Choice D rationale:

While it’s important to always follow the instructions on the bottle when giving medication, aspirin should not be used in children or teenagers with chickenpox due to the risk of Reye’s syndrome. Therefore, this advice could potentially lead to a dangerous situation.

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The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy. Which other medication or medication class, if ordered, would be a potential interaction concern?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A young adult calls the clinic to ask for a prescription for a new flu drug. He says he has had the flu for almost 4 days and just heard about a drug that can reduce the symptoms. What is the nurse’s best response to his request?

Correct Answer is C

Explanation

A 6-year-old child who has chickenpox also has a fever of 102.9 F (39.4 C). The child’s mother asks the nurse if she should use aspirin to reduce the fever. What is the best response by the nurse?

Correct Answer is C

Explanation

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The nurse is reviewing the medication orders for a patient who will be receiving aminoglycoside therapy.
Which other medication or medication class, if ordered, would be a potential interaction concern?