What client is most likely to have impaired drug metabolism?
A client who has a diagnosis of hepatitis C
A client who is being treated for basal cell skin cancer
A client who requires dialysis for renal failure
A client who is dehydrated following several days of diarrhea
The Correct Answer is A
A. Clients with hepatitis C experience liver impairment, which is crucial for drug metabolism; hence, they are likely to have impaired drug metabolism.
B. Treatment for basal cell skin cancer typically does not affect liver function significantly, so drug metabolism is less likely to be impaired.
C. Clients requiring dialysis have impaired renal function, affecting drug excretion more than metabolism, so they may not necessarily have impaired drug metabolism.
D. Dehydration following diarrhea can affect the body's overall function, but it is less directly related to impaired drug metabolism compared to liver dysfunction.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Hypertension can affect drug distribution to some extent due to altered perfusion but is not the most significant factor impacting distribution, especially for a local condition like cellulitis.
B. Liver dysfunction primarily affects the metabolism and clearance of drugs rather than their distribution, although it may indirectly influence distribution by altering protein binding.
C. Peripheral vascular disease significantly impacts blood flow to the extremities, which can hinder the distribution of the antibiotic to the affected area (the left leg) where the cellulitis is present, leading to reduced drug efficacy.
D. Diverticulitis disease primarily affects the gastrointestinal system and would not directly influence the distribution of an antibiotic used to treat cellulitis in the leg.
Correct Answer is B
Explanation
A. While dietary intake is important, especially regarding sodium and fluid balance, it is not the highest priority compared to monitoring blood pressure.
B. Monitoring the client's blood pressure is essential to evaluate the effectiveness of the prescribed antihypertensive medications and to ensure the client is within the target range for managing her hypertension.
C. Weighing the client is important for monitoring fluid retention, especially with hydrochlorothiazide, but it is secondary to direct blood pressure monitoring.
D. Monitoring the respiratory rate is generally less critical in this scenario unless there are specific concerns related to medication side effects or respiratory conditions.
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