Drugs can produce a wide variety of effects in addition to the desired pharmacological effect. Sometimes the drug dose can be adjusted so that the desired effect is achieved without producing undesired secondary reactions. Which are examples of this secondary action?

A. Rebound hypertension can occur if antihypertensive medications are abruptly stopped, but it is not a direct reason for switching from an ACE inhibitor to an angiotensin II receptor blocker.

B. A persistent cough is a well-known side effect of ACE inhibitors due to the accumulation of bradykinin. If the client experienced this side effect, it would likely prompt the healthcare provider to switch to an angiotensin II receptor blocker, which does not typically cause this issue.

C. A transient ischemic attack (TIA) would require urgent intervention but is not a reason for changing from an ACE inhibitor to an angiotensin II receptor blocker.

D. Non-adherence to ACE inhibitor treatment may lead to ineffective blood pressure control but would not directly justify a switch to a different class of medication.

A. Hypertension is not a common side effect of antiplatelet therapy; rather, it may be managed or monitored during treatment.

B. Gastrointestinal bleeding is a well-documented side effect of antiplatelet medications like clopidogrel, as they inhibit platelet aggregation and can increase bleeding risk.

C. Hyperglycemia is not typically associated with antiplatelet therapy; it is more commonly related to corticosteroids or certain diabetic medications.

D. Tachycardia is not a common side effect of antiplatelet therapy; cardiovascular effects are usually related to the management of existing conditions.