What is the function of acetylcholinesterase?
To synthesize acetylcholine
To transport acetylcholine across the synaptic cleft
To break down acetylcholine into acetate and choline
To increase the release of dopamine at the synapse
The Correct Answer is C
Acetylcholine (ACh) is a key neurotransmitter involved in both the central and peripheral nervous systems, particularly at neuromuscular junctions and autonomic synapses. After ACh is released into the synaptic cleft, its action must be rapidly terminated to allow precise control of nerve signaling and prevent continuous stimulation. This termination is achieved by enzymatic degradation. Acetylcholinesterase is the enzyme responsible for this process, ensuring proper synaptic function and muscle relaxation.
A. To synthesize acetylcholine: acetylcholine is synthesized by the enzyme choline acetyltransferase (ChAT), not acetylcholinesterase. ChAT combines choline and acetyl-CoA within the presynaptic neuron to form acetylcholine. Acetylcholinesterase functions after release, not during synthesis.
B. To transport acetylcholine across the synaptic cleft: acetylcholine is not actively transported across the synaptic cleft. Instead, it is released by exocytosis from presynaptic vesicles and diffuses passively across the synaptic gap to bind receptors on the postsynaptic membrane. No transport protein carries it across the cleft.
C. To break down acetylcholine into acetate and choline: acetylcholinesterase rapidly hydrolyzes acetylcholine in the synaptic cleft into acetate and choline. This enzymatic breakdown terminates the signal at cholinergic synapses, preventing continuous stimulation of the postsynaptic receptor. The choline produced is then recycled back into the presynaptic neuron for resynthesis of acetylcholine. This mechanism ensures precise and rapid control of neural transmission.
D. To increase the release of dopamine at the synapse: acetylcholinesterase is specific to acetylcholine and does not influence dopamine release. Dopamine release is regulated by different enzymes and transport mechanisms within dopaminergic neurons. Acetylcholinesterase has no role in modulating dopamine levels or synaptic release.
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Related Questions
Correct Answer is C
Explanation
The highlighted structure is the gluteus maximus, the largest and most superficial muscle of the gluteal region. It forms the bulk of the buttock and originates from the posterior ilium, sacrum, coccyx, and sacrotuberous ligament, inserting into the iliotibial tract and femur. Its primary physiological role is powerful hip extension, especially during actions such as climbing stairs, rising from a seated position, and running. It also contributes to lateral rotation and stabilization of the pelvis and trunk during upright posture and locomotion.
A. Gluteus medius: The gluteus medius lies deep to the gluteus maximus and is located on the lateral aspect of the ilium. It functions primarily in hip abduction and pelvic stabilization during single-leg stance, preventing pelvic drop on the opposite side. Unlike the gluteus maximus, it is not the primary muscle forming the bulk of the buttock and is less superficial.
B. Gluteus minimus: The gluteus minimus is the smallest and deepest of the gluteal muscles, positioned beneath the gluteus medius. It assists in hip abduction and medial rotation of the thigh. It is not visible superficially and does not form the prominent contour of the buttock, making it distinct from the gluteus maximus.
C. Gluteus maximus: The gluteus maximus is a large, thick, quadrangular muscle forming the superficial mass of the buttock. It is the primary extensor of the hip joint and is heavily engaged in powerful movements such as standing from a seated position, running, and climbing. It also contributes to external rotation and supports the iliotibial tract for lateral stability of the knee. Its size, location, and function make it the correct identification.
D. Piriformis: The piriformis is a deep gluteal muscle originating from the anterior sacrum and inserting on the greater trochanter of the femur. It functions mainly in lateral rotation of the hip when the hip is extended and assists in abduction when the hip is flexed. It is located deep within the gluteal region and is not responsible for forming the surface contour of the buttock like the gluteus maximus.
Correct Answer is B
Explanation
Biological organization in multicellular organisms follows a hierarchical structure that increases in complexity from the smallest functional components to complete organ systems. Each level builds upon the previous one, with specialized structures performing increasingly coordinated functions. This organization ensures efficiency in carrying out life processes such as metabolism, transport, and regulation. Understanding this hierarchy is fundamental to anatomy and physiology, as it explains how simple cellular components form complex living systems.
A. Cells → organelles → tissues → organs → organ systems: This option reverses the relationship between cells and organelles. Organelles are subcellular structures found within cells and therefore must come before cells in the hierarchy. Placing cells before organelles disrupts the correct progression of biological organization. While the rest of the sequence is partially correct, the initial order makes the entire option inaccurate.
B. Organelles → cells → tissues → organs → organ systems: This accurately reflects the increasing levels of biological organization. Organelles are the smallest functional structures within cells, performing specific tasks such as energy production or protein synthesis. Cells are the basic units of life, which combine to form tissues with specialized functions. Tissues then form organs, and organs work together in organ systems to maintain the survival of the organism.
C. Tissues → organelles → cells → organs → organ systems: This option places tissues before cells and organelles, which reverses the correct biological hierarchy. Tissues are composed of groups of cells, not the other way around. Additionally, organelles must exist within cells, so they cannot follow tissues in the sequence. This disrupts the foundational structure of biological organization.
D. Organ systems → organs → tissues → cells → organelles: This presents a decreasing order of complexity rather than an increasing one. While organ systems are the highest level of organization, they should appear last in a sequence showing increasing complexity. This arrangement reverses the correct physiological progression from simple to complex structures.
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