When administering medications, a nurse must know a client's medical history and pharmacokinetics of prescribed medications because most drugs are metabolized in the:
Lungs
Liver
Kidney
Colon
The Correct Answer is B
Choice A reason: Lungs excrete volatile drugs like anesthetics; most medications aren’t metabolized here, as they lack the cytochrome enzymes needed for broad drug breakdown.
Choice B reason: The liver is the primary site; cytochrome P450 enzymes metabolize most drugs, converting them into active or excretable forms, critical for pharmacokinetics.
Choice C reason: Kidneys excrete metabolites; they filter, not metabolize, most drugs, relying on prior liver processing, making them secondary in the metabolic pathway.
Choice D reason: The colon absorbs some drugs but doesn’t metabolize most; its role is minimal compared to the liver’s extensive enzymatic drug transformation capacity.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A reason: Vastus lateralis is muscle; insulin given intramuscularly absorbs too fast, risking hypoglycemia, unlike the slower, safer subcutaneous route intended.
Choice B reason: Deltoid is also muscle; subcutaneous insulin isn’t given here as it’s not fatty enough, leading to unpredictable absorption rates versus abdominal tissue.
Choice C reason: Intravenous line is for IV drugs; insulin via IV is rare and only in emergencies, not standard subcutaneous orders, risking rapid overdose effects.
Choice D reason: Abdominal fat is ideal for subcutaneous insulin; it ensures steady absorption into capillaries, maintaining glycemic control per pharmacokinetic principles.
Correct Answer is B
Explanation
Choice A reason: 5 mL gives 125 mg; this underdoses the 175 mg order, reducing Ceclor’s antibacterial effect, risking persistent ear infection due to insufficient concentration.
Choice B reason: 7 mL is correct; 175 mg divided by 125 mg/5 mL equals 7 mL, delivering the exact cephalosporin dose for effective otitis media treatment.
Choice C reason: 10 mL provides 250 mg; this overdoses Ceclor, risking gastrointestinal upset or resistance, exceeding the therapeutic need for the infection safely.
Choice D reason: 14 mL yields 350 mg; this extreme overdose amplifies side effects like diarrhea or toxicity, far beyond the ordered 175 mg dose requirement.
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