Where is iodide located in the thyroid gland?
Lumen of follicle
Secretory vesicles inside follicular cells
Golgi apparatus of parafollicular cells
Cytoplasm of follicular cells
The Correct Answer is A
a) Lumen of follicle: Iodide is actively transported into follicular cells, then secreted into the follicular lumen, where it becomes oxidized and incorporated into thyroglobulin during the synthesis of thyroid hormones (T3 and T4).
b) Secretory vesicles inside follicular cells: These vesicles may contain thyroglobulin, but iodide is concentrated in the lumen for hormone synthesis.
c) Golgi apparatus of parafollicular cells: Parafollicular (C) cells produce calcitonin, not thyroid hormones.
d) Cytoplasm of follicular cells: While iodide is transported into the cytoplasm briefly, its major functional location is in the lumen.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
a) TRH → production of T3 and T4 → TSH: Incorrect order; TSH stimulates T3/T4 production, not the other way around.
b) TSH → production of T3 and T4 → TRH: Incorrect; this reverses the hypothalamic-pituitary-thyroid (HPT) axis.
c) TSH → TRH → production of T3 and T4: Incorrect sequence; the hypothalamus releases TRH before the pituitary releases TSH.
d) thyrotropin-releasing hormone (TRH) → thyroid-stimulating hormone (TSH) → production of T3 and T4: This reflects the HPT axis: TRH is released by the hypothalamus (first tier). TSH is secreted by the anterior pituitary (second tier). T3 and T4 are produced by the thyroid gland (third tier)
Correct Answer is C
Explanation
a) The location of the tissue or organ with respect to the circulatory path: Hormones are carried through the entire bloodstream, so all tissues are exposed. Proximity doesn’t determine responsiveness.
b) The membrane potential of the cells of the target organ: Membrane potential may affect nerve impulse conduction, but not hormone specificity.
c) the presence of the appropriate receptors on the cells of the target tissue or organ: Hormones act only on target cells that express specific receptors for them. No receptor = no response.
d) All hormones stimulate any and all cell types because hormones are powerful and nonspecific: Hormones are highly specific and only act on cells with matching receptors.
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