Which ethical principle is most important when soliciting informed consent from a patient?

A. Administering an enema every third day may be too infrequent to effectively manage constipation. Enemas are generally not a first-line solution for constipation prevention in patients on long-term opioid therapy.
B. Constipation is nothing to worry about; take your medicine is incorrect because constipation is a common and preventable side effect of opioid use. It should be addressed proactively.
C. Only taking morphine when experiencing the most severe pain could lead to uncontrolled pain. It is important for cancer pain to be managed consistently, and adjusting the timing of medication is not recommended.
D. Increasing fluids and high-fiber foods, and using a mild laxative is the most appropriate recommendation. It helps prevent constipation, which is a common side effect of opioid use. Mild laxatives can also be helpful, but regular bowel care is essential.

A. Valsartan (Diovan) is an angiotensin II receptor blocker (ARB), and although it can cause side effects like dizziness or elevated potassium levels, it is less commonly associated with angioedema compared to ACE inhibitors.
B. Amlodipine (Norvasc) is a calcium channel blocker, and while it can cause edema, it does not typically cause facial and tongue swelling.
C. Enalapril (Vasotec) is an ACE inhibitor and is known to cause angioedema, a serious side effect that involves swelling of the face, lips, tongue, or throat. This can lead to difficulty breathing or speaking, and it requires immediate medical attention.
D. Metoprolol succinate (Toprol XL) is a beta-blocker and is not commonly associated with angioedema. It may cause other side effects like bradycardia or hypotension but not facial or tongue swelling.