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Which of the following drugs inhibit bacterial beta-lactamase?

A.

goldenseal

B.

ceftriaxone (Rocephin)

C.

penicillin

D.

Zosyn (piperacillin/tazobactam)

Answer and Explanation

The Correct Answer is D

A.Goldenseal:

Goldenseal is a plant commonly used in herbal medicine, but it is not a drug that specifically inhibits bacterial beta-lactamase. While goldenseal may have antimicrobial properties, it is not typically used as a beta-lactamase inhibitor in the treatment of bacterial infections.

B. Ceftriaxone (Rocephin):

Ceftriaxone is a third-generation cephalosporin antibiotic. While it is an effective antibiotic for treating a wide range of bacterial infections, it does not have beta-lactamase inhibitor properties. Instead, ceftriaxone is susceptible to degradation by beta-lactamase enzymes produced by certain bacteria.

C. Penicillin:

Penicillin is one of the earliest discovered and most widely used beta-lactam antibiotics. However, many bacteria have developed resistance to penicillin by producing beta-lactamase enzymes. Penicillin itself does not inhibit beta-lactamase; instead, it is often combined with beta-lactamase inhibitors to enhance its effectiveness against beta-lactamase-producing bacteria.

D. Zosyn (piperacillin/tazobactam):

Zosyn is a combination antibiotic containing piperacillin, a broad-spectrum penicillin antibiotic, and tazobactam, a beta-lactamase inhibitor. Tazobactam inhibits the action of beta-lactamase enzymes produced by bacteria, allowing piperacillin to exert its antibacterial effects without being degraded by beta-lactamase. Therefore, Zosyn is the correct answer as it contains a drug that inhibits bacterial beta-lactamase.


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Related Questions

Correct Answer is ["50"]

Explanation

To calculate the infusion rate in gtt/min, the nurse needs to use the formula:

Infusion rate (gtt/min) = Volume (mL) x Drop factor (gtt/mL) / Time (min)

Plugging in the given values, we get:

Infusion rate (gtt/min) = 400 mL x 60 gtt/mL / 480 min

Simplifying, we get:

Infusion rate (gtt/min) = 50 gtt/min

Therefore, the nurse should set the manual IV infusion to deliver 50 gtt/min.

Correct Answer is B

Explanation

A. 36 months:

This duration is longer than typical treatment courses for TB. While treatment for drug-resistant TB may require an extended duration, standard treatment for drug-sensitive TB typically lasts for a shorter period.

B. 6-12 months:

This duration is within the typical range for the treatment of drug-sensitive TB. Standard treatment regimens for drug-sensitive TB usually involve a combination of multiple antibiotics taken for 6 to 9 months, sometimes extending up to 12 months depending on factors such as the severity of the disease and the patient's response to treatment.

C. 2-4 weeks:

This duration is too short for the treatment of TB. TB treatment requires a prolonged course of antibiotics to ensure the complete eradication of the bacteria and to prevent the development of drug resistance.

D. 7-10 days:

This duration is too short for the treatment of TB. TB treatment typically lasts for several months rather than days, as it involves a combination of antibiotics taken for an extended period to effectively treat the infection.

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