Which of the following would reduce the absorption of ciprofloxacin?

Alcohol

Intense physical exertion

Fruit juices, in particular grapefruit juice

Antacids or mineral supplements

Answer and Explanation

The Correct Answer is D

A.Alcohol:

Alcohol consumption does not directly reduce the absorption of ciprofloxacin. However, alcohol can interact with certain medications and may exacerbate side effects such as dizziness, drowsiness, and gastrointestinal upset. It’s generally advisable to avoid excessive alcohol consumption while taking ciprofloxacin, but alcohol itself does not significantly affect the absorption of the medication.

B. Intense physical exertion:

Intense physical exertion is unlikely to directly reduce the absorption of ciprofloxacin. However, gastrointestinal motility may increase during intense exercise, potentially affecting the absorption of oral medications. In some cases, gastrointestinal disturbances associated with physical exertion may affect the absorption of ciprofloxacin, but this effect is generally minor and not a significant concern for most individuals.

C. Fruit juices, in particular grapefruit juice:

Grapefruit juice is known to interact with certain medications by inhibiting intestinal enzymes responsible for drug metabolism, leading to increased drug concentrations in the bloodstream. However, ciprofloxacin is not significantly affected by grapefruit juice. In fact, fruit juices, including grapefruit juice, are generally not known to reduce the absorption of ciprofloxacin.

D. Antacids or mineral supplements:

Antacids and mineral supplements containing aluminum, magnesium, calcium, or iron can significantly reduce the absorption of ciprofloxacin when taken concurrently. These substances can form complexes with ciprofloxacin in the gastrointestinal tract, reducing its bioavailability. Therefore, it’s recommended to avoid taking antacids or mineral supplements containing these minerals within a few hours before or after taking ciprofloxacin to avoid interference with its absorption.

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Correct Answer is D

Explanation

A.Goldenseal:

Goldenseal is a plant commonly used in herbal medicine, but it is not a drug that specifically inhibits bacterial beta-lactamase. While goldenseal may have antimicrobial properties, it is not typically used as a beta-lactamase inhibitor in the treatment of bacterial infections.

B. Ceftriaxone (Rocephin):

Ceftriaxone is a third-generation cephalosporin antibiotic. While it is an effective antibiotic for treating a wide range of bacterial infections, it does not have beta-lactamase inhibitor properties. Instead, ceftriaxone is susceptible to degradation by beta-lactamase enzymes produced by certain bacteria.

C. Penicillin:

Penicillin is one of the earliest discovered and most widely used beta-lactam antibiotics. However, many bacteria have developed resistance to penicillin by producing beta-lactamase enzymes. Penicillin itself does not inhibit beta-lactamase; instead, it is often combined with beta-lactamase inhibitors to enhance its effectiveness against beta-lactamase-producing bacteria.

D. Zosyn (piperacillin/tazobactam):

Zosyn is a combination antibiotic containing piperacillin, a broad-spectrum penicillin antibiotic, and tazobactam, a beta-lactamase inhibitor. Tazobactam inhibits the action of beta-lactamase enzymes produced by bacteria, allowing piperacillin to exert its antibacterial effects without being degraded by beta-lactamase. Therefore, Zosyn is the correct answer as it contains a drug that inhibits bacterial beta-lactamase.

A. 36 months B. 6-12 months C. 2-4 weeks D. 7-10 days

Correct Answer is B

Explanation

A. 36 months:

This duration is longer than typical treatment courses for TB. While treatment for drug-resistant TB may require an extended duration, standard treatment for drug-sensitive TB typically lasts for a shorter period.

B. 6-12 months:

This duration is within the typical range for the treatment of drug-sensitive TB. Standard treatment regimens for drug-sensitive TB usually involve a combination of multiple antibiotics taken for 6 to 9 months, sometimes extending up to 12 months depending on factors such as the severity of the disease and the patient's response to treatment.

C. 2-4 weeks:

This duration is too short for the treatment of TB. TB treatment requires a prolonged course of antibiotics to ensure the complete eradication of the bacteria and to prevent the development of drug resistance.

D. 7-10 days:

This duration is too short for the treatment of TB. TB treatment typically lasts for several months rather than days, as it involves a combination of antibiotics taken for an extended period to effectively treat the infection.

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Which of the following would reduce the absorption of ciprofloxacin?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

Which of the following drugs inhibit bacterial beta-lactamase?

Correct Answer is D

Explanation

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Correct Answer is B

Explanation

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