Which of the following hormones is secreted by the anterior pituitary gland?

A. Oxytocin:Oxytocin is synthesized in the hypothalamus and released from the posterior pituitary, not the anterior pituitary.
B. Antidiuretic hormone (ADH):ADH (vasopressin) is produced in the hypothalamus and released from the posterior pituitary, so it is not secreted by the anterior pituitary.
C. Cortisol:Cortisol is produced by the adrenal cortex in response to ACTH from the anterior pituitary; the anterior pituitary does not secrete cortisol itself.
D. Growth hormone (GH):Growth hormone is synthesized and secreted by the anterior pituitary and acts on many tissues to promote growth and metabolism.

A. Negative feedback on the thyroid gland:Cushing's disease involves cortisol dysregulation and does not primarily disrupt negative feedback of the thyroid axis.
B. Positive feedback on the pituitary gland:Pituitary-driven Cushing's involves excess ACTH but the disrupted mechanism is not a physiological positive feedback loop on the pituitary.
C. Negative feedback on the hypothalamus and pituitary:Elevated cortisol should suppress CRH and ACTH via negative feedback; in Cushing's disease this feedback loop is impaired because a pituitary adenoma continues to produce ACTH despite high cortisol.
D. Positive feedback on the adrenal cortex:The adrenal cortex responds to ACTH but physiological regulation of cortisol does not operate via positive feedback on the cortex.