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Nephrotic Syndrome
Nephrotic Syndrome ( 36 Questions)
Incorrect. Nephrotic syndrome is characterized by increased proteinuria, indicating the loss of proteins from the bloodstream, not increased filtration of proteins into the urine.
Incorrect. Thickening of the glomerular basement membrane is a feature of some kidney diseases but is not the primary abnormality in nephrotic syndrome.
Incorrect. Nephrotic syndrome is associated with increased permeability of the glomerular capillaries, allowing proteins to pass through into the urinary space.
Correct. Disruption of the glomerular filtration barrier, which includes the glomerular endothelium, basement membrane, and podocytes, leads to the key features of nephrotic syndrome, such as proteinuria and hypoalbuminemia.
A) Incorrect. Nephrotic syndrome is characterized by increased proteinuria, indicating the loss of proteins from the bloodstream, not increased filtration of proteins into the urine.
B) Incorrect. Thickening of the glomerular basement membrane is a feature of some kidney diseases but is not the primary abnormality in nephrotic syndrome.
C) Incorrect. Nephrotic syndrome is associated with increased permeability of the glomerular capillaries, allowing proteins to pass through into the urinary space.
D) Correct. Disruption of the glomerular filtration barrier, which includes the glomerular endothelium, basement membrane, and podocytes, leads to the key features of nephrotic syndrome, such as proteinuria and hypoalbuminemia.