75 mcg=____mg (Fill in the blank with the numerical value only)

A. Cardiotoxicity: While NSAIDs can contribute to cardiovascular risks such as hypertension and fluid retention, nephrotoxicity is the more direct explanation for the elevated kidney function tests and potassium level. Cardiotoxicity typically presents with symptoms like heart failure or arrhythmias rather than kidney-related lab abnormalities.
B. Nephrotoxicity: NSAIDs inhibit prostaglandin synthesis, which plays a key role in maintaining renal blood flow, especially in older adults or those with preexisting renal impairment. Chronic NSAID use can reduce glomerular filtration, leading to elevated creatinine, hyperkalemia, and worsening blood pressure control, all of which are evident in this patient.
C. Neurotoxicity: Neurotoxic effects are not commonly associated with NSAID use. Symptoms of neurotoxicity include confusion or seizures, which are not relevant to the clinical findings in this scenario.
D. Hepatotoxicity: NSAID-induced liver injury is rare and would typically present with elevated liver enzymes (AST, ALT), not elevated creatinine or potassium. The current lab findings and blood pressure changes are more consistent with kidney involvement.

A. "Increase your fluid intake to 2–3 liters per day.": Increased fluid intake helps dilute uric acid levels and promotes renal excretion, reducing the risk of kidney stones—a common complication in patients taking allopurinol. Maintaining hydration is a key part of long-term gout management.
B. "Discontinue the medication once symptoms improve.": Allopurinol is a maintenance medication meant to prevent gout flares by lowering uric acid levels over time. Stopping it when symptoms improve can lead to rebound hyperuricemia and recurrent attacks.
C. "Double the dose if a dose is missed.": Doubling a missed dose can increase the risk of toxicity, including skin rash, liver dysfunction, and hypersensitivity reactions. If a dose is missed, it should be taken as soon as remembered unless it's almost time for the next dose.
D. "Take the medication only during acute gout attacks.": Allopurinol is not intended for acute gout relief; it can actually worsen or trigger flares when initiated during an attack. It is used for chronic urate-lowering therapy and should be taken consistently.