A 21-year-old patient with a known history of sickle cell anemia presents to the emergency department with severe pain in the lower back and joints, fatigue, and fever. What is the most likely cause of these symptoms?

Acute lymphoblastic leukemia

Iron-deficiency anemia

Vaso-occlusive crisis

Pneumonia

Answer and Explanation

The Correct Answer is C

Choice A Reason:

Acute lymphoblastic leukemia (ALL) is a type of cancer that affects the blood and bone marrow. While it can cause symptoms such as fatigue and fever, it is less likely to cause severe pain in the lower back and joints, which are more characteristic of a vaso-occlusive crisis in sickle cell anemia. ALL typically presents with symptoms like frequent infections, easy bruising or bleeding, and bone pain, but the combination of severe pain, fatigue, and fever in a patient with sickle cell anemia points more towards a vaso-occlusive crisis.

Choice B Reason:

Iron-deficiency anemia is a condition where there is a lack of adequate iron to form healthy red blood cells. Symptoms include fatigue, weakness, and pale skin, but it does not typically cause severe pain in the lower back and joints or fever. The presence of severe pain and fever in a patient with sickle cell anemia is more indicative of a vaso-occlusive crisis rather than iron-deficiency anemia.

Choice C Reason:

Vaso-occlusive crisis is a common and painful complication of sickle cell anemia. It occurs when sickled red blood cells block blood flow to parts of the body, causing severe pain, often in the back, joints, and abdomen. This condition can also lead to fever and fatigue due to the body’s inflammatory response and the reduced oxygen delivery to tissues. Given the patient’s history of sickle cell anemia and the described symptoms, a vaso-occlusive crisis is the most likely cause.

Choice D Reason:

Pneumonia is an infection that inflames the air sacs in one or both lungs, which can cause symptoms such as fever, chills, and difficulty breathing. While pneumonia can occur in patients with sickle cell anemia, it is less likely to cause severe pain in the lower back and joints. The combination of severe pain, fatigue, and fever in this patient is more consistent with a vaso-occlusive crisis.

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Correct Answer is D

Explanation

Choice A Reason:

Diabetes Insipidus (DI) is characterized by excessive urination and thirst due to a deficiency of antidiuretic hormone (ADH) or a renal insensitivity to ADH. Patients with DI typically present with hypernatremia (high serum sodium) and low urine osmolality, which contrasts with the findings of low serum sodium and high urine osmolality in this patient.

Choice B Reason:

Adrenal insufficiency can cause hyponatremia and hyperkalemia due to a deficiency in aldosterone and cortisol. However, it usually presents with low serum osmolality and low urine sodium, which does not align with the patient’s laboratory results of high urine osmolality and elevated urine sodium.

Choice C Reason:

Hyperaldosteronism leads to increased sodium reabsorption and potassium excretion, resulting in hypernatremia and hypokalemia. This condition does not match the patient’s findings of hyponatremia and high urine osmolality.

Choice D Reason:

Syndrome of inappropriate Antidiuretic Hormone (SIADH) is characterized by excessive release of ADH, leading to water retention, hyponatremia, and concentrated urine. The patient’s laboratory results of low serum sodium, low serum osmolality, high urine osmolality, and elevated urine sodium are consistent with SIADH. This condition causes the kidneys to reabsorb water, diluting the blood and concentrating the urine.

A. Primary hyperparathyroidism B. Chronic kidney disease C. Vitamin D deficiency D. Hypoparathyroidism

Correct Answer is D

Explanation

Choice A Reason:

Primary hyperparathyroidism is characterized by elevated PTH levels, which lead to increased serum calcium levels and decreased serum phosphate levels. The patient’s lab results show low PTH and low serum calcium, which are not consistent with primary hyperparathyroidism.

Choice B Reason:

Chronic kidney disease (CKD) can cause disturbances in calcium and phosphate metabolism, but it typically presents with elevated PTH levels due to secondary hyperparathyroidism. The patient’s low PTH levels make CKD an unlikely diagnosis in this context.

Choice C Reason:

Vitamin D deficiency can lead to low serum calcium levels, but it usually results in elevated PTH levels as the body attempts to compensate for the low calcium. The patient’s low PTH levels do not align with a diagnosis of vitamin D deficiency.

Choice D Reason:

Hypoparathyroidism is characterized by low serum calcium, low PTH levels, and elevated serum phosphate levels. This condition occurs when the parathyroid glands do not produce enough PTH, leading to the observed lab results and symptoms such as tingling, muscle cramps, and fatigue. The patient’s lab results are consistent with hypoparathyroidism.

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A 21-year-old patient with a known history of sickle cell anemia presents to the emergency department with severe pain in the lower back and joints, fatigue, and fever. What is the most likely cause of these symptoms?

Nursing Test Bank

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Correct Answer is D

Explanation

Correct Answer is D

Explanation

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