A client is admitted for acute renal failure and the nurse is monitoring their response to medications. Which pharmacokinetic principle does the nurse understand will be affected in this patient?

To find the rate in mL/hr, we need to convert the time from minutes to hours and then divide the volume by the time. Here are the steps:

1. Convert 30 minutes to hours:

30 minutes/ (60 minutes/hour)= 0.5 hours

2. Calculate the rate in mL/hr:

250 mL/ 0.5 hours = 500 mL

So, the nurse will set the pump to deliver the fluid at a rate of 500 mL/hr.

Choice A reason: This statement is false. The nurse does not need to assess the client's INR level, as INR stands for international normalized ratio, which is a test that measures the blood clotting time. Glipizide is an oral antidiabetic drug that lowers blood glucose levels by stimulating the release of insulin from the pancreas. It does not affect the blood clotting time or the INR level.

Choice B reason: This statement is false. The nurse does not need to assess the client's last bowel movement, as this is not relevant to the client's condition. Glipizide is an oral antidiabetic drug that lowers blood glucose levels by stimulating the release of insulin from the pancreas. It does not affect the bowel movements or the gastrointestinal function.

Choice C reason: This statement is true. The nurse's priority assessment is to check the client's blood glucose level, as the client may have hypoglycemia, which is a condition where the blood glucose level is too low. Hypoglycemia can cause confusion, sweating, and rapid heart rate, which are the symptoms that the client is experiencing. Hypoglycemia can be a serious and life-threatening complication of glipizide therapy, as it can lead to seizures, coma, or death if not treated promptly.

Choice D reason: This statement is false. The nurse does not need to assess the client's apical heart rate, as this is not the most urgent assessment. Glipizide is an oral antidiabetic drug that lowers blood glucose levels by stimulating the release of insulin from the pancreas. It can also lower the blood pressure and heart rate, but not to a dangerous level. However, the client's tachycardia may be a sign of hypoglycemia, which is a more critical condition that requires immediate intervention..