A client is admitted with bipolar disorder and lithium carbonate is prescribed. Before administering the daily dose, the practical nurse (PN) plans to monitor the client’s serum lithium levels. Which physiologic action necessitates frequent monitoring of serum lithium levels?

Serum levels reflect client compliance and support behavior changes

Sodium influences a narrow margin between therapeutic and toxic levels

Myelosuppression and agranulocytosis are common side effects

Foods containing tyramine influence the drug’s metabolism

Answer and Explanation

The Correct Answer is B

Choice A reason: Serum lithium levels indicate compliance but do not directly explain the need for frequent monitoring. Lithium’s therapeutic effect stabilizes mood, but monitoring is primarily due to its narrow therapeutic index, where small changes in blood levels can cause toxicity, not just behavioral changes or compliance.

Choice B reason: Sodium levels affect lithium excretion, as both compete for renal reabsorption. Low sodium increases lithium retention, risking toxicity, while high sodium increases excretion, reducing efficacy. Lithium’s narrow therapeutic range (0.6–1.2 mEq/L) necessitates frequent monitoring to prevent toxic levels, which can cause neurological or cardiac issues.

Choice C reason: Myelosuppression and agranulocytosis are not common lithium side effects. Lithium may cause mild leukocytosis, not suppression. Toxicity risks, like neurological or renal effects, drive monitoring needs, not hematologic issues. This choice is incorrect, as it misrepresents lithium’s side effect profile.

Choice D reason: Tyramine, relevant to monoamine oxidase inhibitors, does not influence lithium metabolism. Lithium’s pharmacokinetics are affected by sodium and renal function, not dietary tyramine. This choice is incorrect, as it falsely links a dietary factor to lithium’s monitoring requirements.

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Correct Answer is B

Explanation

Choice A reason: Stopping disulfiram for nausea or vomiting is incorrect, as these are expected in alcohol reactions, not side effects warranting discontinuation. Disulfiram inhibits aldehyde dehydrogenase, causing acetaldehyde buildup if alcohol is consumed, leading to these symptoms, which reinforce alcohol avoidance.

Choice B reason: Avoiding all alcohol, including in cough syrups, is critical, as disulfiram causes severe reactions (flushing, nausea) by blocking acetaldehyde metabolism. Even small amounts trigger symptoms, reinforcing abstinence in alcohol dependence treatment, making this the most important instruction for safety and efficacy.

Choice C reason: Taking disulfiram at the same time daily promotes adherence but is less critical than avoiding alcohol, which directly prevents severe reactions. Consistency aids therapeutic levels, but alcohol exposure poses immediate health risks, making this instruction secondary.

Choice D reason: Weekly blood tests are not standard for disulfiram, as therapeutic levels are not routinely monitored, and sodium is unaffected. Liver function may be checked periodically, but alcohol avoidance is the priority to prevent acute reactions, making this choice incorrect.

A. Appetite B. Sleep log C. Heart rate D. Daily weights

Correct Answer is C

Explanation

Choice A reason: Appetite changes may occur with levothyroxine due to metabolic effects, but they are not the most critical side effect. Excessive thyroid hormone can overstimulate metabolism, but cardiovascular effects, like tachycardia, are more immediate and dangerous, making appetite monitoring less urgent.

Choice B reason: Sleep disturbances may result from levothyroxine’s stimulatory effects, but they are less severe than cardiovascular risks. Overdose can cause insomnia by increasing metabolism, but heart rate is a more direct indicator of hyperthyroidism, which poses greater health risks, making this choice secondary.

Choice C reason: Heart rate is critical to monitor, as levothyroxine increases metabolism, potentially causing tachycardia or arrhythmias if overdosed. Excess thyroid hormone mimics hyperthyroidism, stressing the cardiovascular system, which can lead to palpitations or heart failure, making this the most important parameter for side effect detection.

Choice D reason: Daily weights track fluid or metabolic changes but are less specific for levothyroxine side effects. Weight loss may occur with excess dosing, but cardiovascular effects, like increased heart rate, are more immediate and life-threatening, requiring closer monitoring than weight fluctuations.

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A client is admitted with bipolar disorder and lithium carbonate is prescribed. Before administering the daily dose, the practical nurse (PN) plans to monitor the client’s serum lithium levels. Which physiologic action necessitates frequent monitoring of serum lithium levels?

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Naxlex Comprehensive Predictor Exams

The practical nurse (PN) is reviewing the discharge medication instructions with a client for disulfiram. Which instruction should the PN reinforce with the client?

Correct Answer is B

Explanation

The practical nurse (PN) is providing discharge instructions to a client who had a partial thyroidectomy. When explaining the actions of the prescribed thyroid supplement levothyroxine sodium, which parameter should the PN tell the client is most important to monitor for potential side effects?

Correct Answer is C

Explanation

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