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A client is curious about the impact of chronic stress on the development of depression. Which statement accurately reflects the relationship between chronic stress and depression according to the text?

"Chronic stress can lead to hyperactivity of the HPA axis, resulting in elevated levels of cortisol that can support neuronal growth and survival.".

"Chronic stress can lead to hypoactivity of the HPA axis, resulting in reduced levels of cortisol that enhance neurogenesis and synaptic plasticity.".

"Chronic stress can lead to hyperactivity of the HPA axis, resulting in elevated levels of cortisol that can impair neurogenesis and synaptic plasticity.".

"Chronic stress can lead to hypoactivity of the HPA axis, resulting in reduced levels of cortisol that improve neurotrophic factors and cognitive function.".

Answer and Explanation

The Correct Answer is C

Choice A rationale:

Chronic stress is known to activate the Hypothalamic-Pituitary-Adrenal (HPA) axis, which leads to increased cortisol production. While cortisol is important for various physiological functions, chronic elevation of cortisol due to stress can actually have detrimental effects on the brain. Elevated cortisol levels have been associated with impaired neurogenesis (the formation of new neurons) and synaptic plasticity (the ability of synapses to change and adapt), both of which play crucial roles in maintaining cognitive function and mental health.

Choice B rationale:

This statement is not accurate. Chronic stress typically leads to hyperactivity, not hypoactivity, of the HPA axis, resulting in increased levels of cortisol. The increased cortisol levels can negatively impact neurogenesis and synaptic plasticity, which are key factors in depression and cognitive function.

Choice C rationale:

This is the correct statement. Chronic stress triggers hyperactivity of the HPA axis, causing elevated levels of cortisol. While cortisol is meant to help the body cope with stress in the short term, chronic elevation can lead to adverse effects on the brain. High cortisol levels have been linked to impaired neurogenesis and synaptic plasticity, contributing to the development of depression and cognitive deficits.

Choice D rationale:

This statement is not accurate. Chronic stress tends to lead to hyperactivity of the HPA axis and elevated cortisol levels. Reduced cortisol levels, as suggested in this choice, are not commonly associated with chronic stress and its impact on depression.

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Correct Answer is ["A","C","E"]

Explanation

Choice A rationale:

The correct answer. A positive family history of mood disorders is a well-established risk factor for developing major depressive disorder (MDD). Genetic factors play a significant role in predisposing individuals to MDD, making it more likely to develop if there's a family history of mood disorders.

Choice B rationale:

Optimistic personality traits are not considered risk factors for developing major depressive disorder (MDD). In fact, having an optimistic personality might serve as a protective factor against developing MDD.

Choice C rationale:

The correct answer. Young age is a risk factor for developing MDD. Adolescents and young adults are particularly susceptible to the onset of depressive disorders due to hormonal changes, emotional challenges, and life transitions during this developmental stage.

Choice D rationale:

High socioeconomic status is not a consistent risk factor for developing major depressive disorder (MDD). While individuals from various socioeconomic backgrounds can develop MDD, the factors contributing to its development are more complex and not solely dependent on socioeconomic status.

Choice E rationale:

The correct answer. Chronic medical conditions are risk factors for developing major depressive disorder (MDD). The stress, emotional toll, and physiological effects of living with a chronic illness can contribute to the onset or exacerbation of depressive symptoms.

A. Electroconvulsive therapy (ECT) and other somatic therapies. B. Pharmacological interventions. C. Herbal supplements. D. Physical exercise. E. Mindfulness-based cognitive therapy (MBCT).

Correct Answer is ["A"]

Explanation

Choice A rationale:

Electroconvulsive therapy (ECT) and other somatic therapies are considered main treatment options for Major Depressive Disorder (MDD). ECT involves passing electric currents through the brain to induce controlled seizures, and it's often used in severe cases of depression that haven't responded to other treatments. Somatic therapies encompass a range of interventions that directly target the body, such as transcranial magnetic stimulation (TMS) and vagus nerve stimulation (VNS). These treatments are supported by extensive research and clinical evidence, particularly for cases where pharmacological interventions haven't been effective or suitable.

Choice B rationale:

Pharmacological interventions are indeed a mainstay in MDD treatment. However, while they are effective for many individuals, they might not work for everyone and can have side effects. Hence, the treatment approach should be tailored to the individual's needs and preferences.

Choice C rationale:

Herbal supplements are not considered main treatment options for MDD according to established clinical guidelines. While some herbal supplements might have anecdotal support for mood enhancement, their efficacy and safety are not well-established through rigorous scientific research and clinical trials.

Choice D rationale:

Physical exercise has been shown to have a positive impact on mood and can be a beneficial adjunct to MDD treatment. However, it's typically not considered a standalone main treatment option. Rather, it's often recommended as a complementary approach alongside other evidence-based treatments.

Choice E rationale:

Mindfulness-based cognitive therapy (MBCT) is a psychological approach that combines mindfulness meditation with cognitive behavioral techniques. While MBCT has shown promise in preventing relapse for individuals with recurrent depression, it's usually used as a psychotherapeutic adjunct to other main treatments like pharmacological interventions or psychotherapy.

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A client is curious about the impact of chronic stress on the development of depression. Which statement accurately reflects the relationship between chronic stress and depression according to the text?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

(Select All That Apply): A nurse is providing care for a client with suspected major depressive disorder (MDD). Which of the following are risk factors for developing MDD? Select all that apply.

Correct Answer is ["A","C","E"]

Explanation

(Select All That Apply): A nurse is educating a group of clients about the treatment approaches for MDD. Which of the following modalities are considered main treatment options for MDD according to the text? Select all that apply.

Correct Answer is ["A"]

Explanation

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