A client who is suffering from an acute gout attack wants to know how colchicine differs from probenecid and allopurinol in its actions. Which of these statements shows the need for further teaching regarding the purpose and use of these medications?
Allopurinol prevents the synthesis of uric acid.
All of these medications should be taken concurrently during an acute attack, and non-steroidal anti-inflammatory drugs (NSAIDs) should be added for pain control.
Colchicine reduces inflammation caused by uric acid.
Probenecid facilitates the elimination of uric acid in the nephrons.
The Correct Answer is B
A) Allopurinol inhibits the synthesis of uric acid, preventing its formation.
B) Colchicine is typically used for gout flares and reduces inflammation but is not usually taken concurrently with probenecid and allopurinol. NSAIDs or corticosteroids are often used for pain control during acute attacks.
C) Colchicine is known for its anti-inflammatory properties but does not prevent uric acid synthesis or facilitate its elimination.
D) Probenecid increases the excretion of uric acid in the urine.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
a) Naloxone does not increase the excretion of opioids by altering serum pH; its primary action is at the receptor level.
b) Naloxone is an opioid receptor antagonist, meaning it blocks or prevents the activation of opioid receptors. This is how it counteracts the effects of opioids like morphine.
c) Naloxone does not regulate the sensitivity of opioid receptors by neurochemical alterations. Its action is more direct as an antagonist.
d) Naloxone is not an agonist; it does not produce opioid-like effects. Instead, it competes with opioids for receptor binding and blocks their effects.
Correct Answer is ["C","D","E"]
Explanation
a) This is false because oral medications can be given to infants if they are in liquid form, have a suitable dose, and are administered with a dropper or syringe. However, oral medications should be given with caution and only when prescribed by a doctor.
b) This is false because lipid-soluble drugs are not easily passed into breast milk and do not affect breastfeeding infants. However, some drugs can be harmful to breastfeeding infants and should be avoided or used with caution by nursing mothers.
c) Immaturity of renal function in infancy affects drug excretion, potentially leading to prolonged drug effects and increased risk of toxicity.
d) Infants are more sensitive to medications that act on the central nervous system, and dose adjustments may be needed to prevent adverse effects.
e) Immature liver function in infants can slow down drug metabolism and elimination, leading to a higher risk of drug accumulation and toxicity.
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