A client with an acute stroke must receive Alteplase 0.9 mg/kg (maximum dose 90 mg) over 60 minutes. The client weighs 220 pounds. How many mg should the client receive? (Round to the nearest tenth, do not use trailing zeros)

A. Recent intake of sildenafil:
While there is a potential drug interaction between atenolol (a beta-blocker) and sildenafil (a phosphodiesterase inhibitor used for erectile dysfunction), this alone would not necessarily be an indication to hold atenolol. Sildenafil can cause hypotension, which might be exacerbated by atenolol, especially in older adults or those with cardiovascular issues. However, this interaction usually requires monitoring rather than immediate discontinuation of atenolol, unless the client is symptomatic (e.g., feeling faint, dizziness). If symptoms of hypotension occur after taking both medications, the nurse would assess the client's condition but would not automatically hold atenolol based solely on this information.

B. Heart rate 52 and blood pressure 90/56: The most concerning finding in a client receiving atenolol (a beta-blocker) for angina is a heart rate of 52 beats per minute (bradycardia) and a blood pressure of 90/56 mmHg (hypotension). Beta-blockers, such as atenolol, work by reducing the heart rate and lowering blood pressure. A heart rate of 52 beats per minute is below the typical threshold of 60 beats per minute and indicates bradycardia, which could worsen due to the medication's effects. Additionally, hypotension (blood pressure 90/56) can be dangerous, especially when combined with bradycardia. Both of these findings suggest that the client may be experiencing excessive beta-blockade, which could lead to severe complications such as cardiogenic shock or arrhythmias. Therefore, the nurse should hold the medication and contact the provider for further assessment and possible adjustment of the treatment plan.

C. Restlessness and mild confusion:
Restlessness and mild confusion could indicate several possible issues, such as hypoxia, electrolyte imbalances, or medication side effects. While beta-blockers can cause side effects like fatigue or depression, restlessness and confusion are not common acute reactions to atenolol. However, if these symptoms are due to hypotension or bradycardia from the atenolol, then holding the medication and notifying the provider may be warranted. Nonetheless, these symptoms alone are not a clear cause to immediately hold atenolol without further assessment.

D. Positional vertigo and wheezing:
Positional vertigo can occur due to a variety of causes, including inner ear issues, hypotension, or even medication side effects. Wheezing, however, raises concerns about potential bronchospasm, which is a known side effect of non-cardioselective beta-blockers. Atenolol is a cardioselective beta-blocker, meaning it is less likely to cause bronchospasm compared to non-cardioselective agents like propranolol. While wheezing could indicate a reaction to the medication, it is not a primary concern with atenolol, unless the client has a history of asthma or chronic obstructive pulmonary disease (COPD). If wheezing occurs, the nurse should still monitor the client but would not necessarily hold atenolol immediately unless the symptoms are severe.

A. Fully compensated respiratory acidosis: Fully compensated respiratory acidosis would involve a low pH (indicative of acidosis), elevated PaCO2 (due to impaired ventilation), and a normal HCO3 level as compensation by the kidneys. The given ABG results show metabolic acidosis with partial respiratory compensation, not respiratory acidosis.

B. Partially compensated respiratory acidosis: In respiratory acidosis, you would expect an elevated PaCO2 (not low, as seen here) and a compensatory increase in HCO3. However, the ABG results show low HCO3 and low PaCO2, indicating that this is metabolic acidosis, not respiratory acidosis.

C. Uncompensated metabolic acidosis: Uncompensated metabolic acidosis would be indicated by a low pH and low bicarbonate (HCO3), with normal PaCO2. Since the PaCO2 is low, this suggests partial respiratory compensation, making this scenario not uncompensated but partially compensated.

D. Partially compensated metabolic acidosis: To interpret these ABG results, let's break down the values:

pH 7.32 (normal range: 7.35–7.45) indicates acidosis, as it is below the normal range.

PaCO2 33 mmHg (normal range: 35–45 mmHg) is low, suggesting that respiratory compensation is occurring to counteract the acidosis. In metabolic acidosis, the lungs typically attempt to blow off CO2 to reduce acid levels, which is why PaCO2 is low here.

HCO3 16 mEq/L (normal range: 22–25 mEq/L) is low, confirming a metabolic acidosis. The low bicarbonate level is characteristic of metabolic acidosis, where the body loses too much bicarbonate or produces too much acid. PaO2 88 mmHg (normal range: 80–95 mmHg) is within the normal range and does not indicate a significant respiratory issue.