A client with atrial fibrillation receives a new prescription for dabigatran. Which instruction should the nurse include in this client's teaching plan?

Eliminate spinach and other green vegetables in the diet.

Continue obtaining scheduled laboratory bleeding tests.

Keep an antidote available in the event of hemorrhage.

Avoid use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Answer and Explanation

The Correct Answer is D

Choice A reason: Spinach and other green vegetables are rich in vitamin K, which is essential for blood clotting. However, dabigatran is not affected by vitamin K intake, unlike warfarin, another anticoagulant drug. Therefore, there is no need to eliminate these foods from the diet.

Choice B reason: Dabigatran does not require routine laboratory monitoring of bleeding parameters, such as prothrombin time (PT) or international normalized ratio (INR), unlike warfarin. Therefore, the client does not need to continue obtaining scheduled laboratory bleeding tests.

Choice C reason: Dabigatran is a direct thrombin inhibitor that prevents the formation of fibrin, the main component of blood clots. In case of a major bleeding event, the antidote for dabigatran is idarucizumab, a monoclonal antibody that binds to dabigatran and reverses its effect. However, this antidote is not readily available in most settings and should only be administered by a health care provider. Therefore, the client should not keep an antidote available at home.

Choice D reason: NSAIDs, such as ibuprofen or naproxen, can increase the risk of bleeding by inhibiting platelet aggregation and damaging the gastric mucosa. Therefore, the client should avoid using these drugs while taking dabigatran. The client should consult with the prescriber before taking any other medications, including over-the-counter or herbal products.

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Correct Answer is B

Explanation

The correct answer is b. Liver function laboratory results.

Choice A reason:

Weight change in the last month can be an important factor to consider for a patient's overall health and may be relevant in the context of depression, as significant weight changes can be a symptom of this condition. However, it is not the most critical piece of information before prescribing duloxetine. Duloxetine is not primarily metabolized by the kidneys, and while weight can affect dosing and efficacy, it is not the most crucial factor to consider before starting treatment.

Choice B reason:

Liver function laboratory results are crucial to obtain before prescribing duloxetine because duloxetine is extensively metabolized by the liver. The prescribing information for duloxetine warns of the potential for hepatotoxicity, and hepatic failure has been reported in some cases. Therefore, it is essential to ensure that the patient's liver function is normal before initiating therapy with duloxetine, as impaired liver function could lead to increased levels of the medication in the body and a higher risk of side effects.

Choice C reason:

Recent use of other antidepressants is important to consider avoiding drug interactions, particularly with monoamine oxidase inhibitors (MAOIs), which can lead to serious, life-threatening side effects if taken together with duloxetine. While this information is important, it is not as critical as liver function, because the primary concern with other antidepressants is the timing of medication changes rather than an absolute contraindication.

Choice D reason:

A family history of mental illness can provide valuable information for understanding a patient's background and potential genetic predispositions to certain conditions. However, this information does not directly impact the safety and initial prescribing of duloxetine. It may be more relevant for long-term treatment considerations and prognosis rather than immediate prescription safety.

A. St. John's Wort can decrease plasma concentrations of cyclosporine. B. Adding the herb can decrease the need for corticosteroids. C. The client probably used this herb to treat depression. D. Ingestion of St. John's Wort can reduce the client's intake of sodium.

Correct Answer is A

Explanation

Choice A reason: This is the most significant information about this finding. St. John's Wort is an herbal supplement that is used for various conditions, such as depression, anxiety, or insomnia. However, it can also interact with many medications, including cyclosporine, which is an immunosuppressant drug that is used to prevent organ rejection after transplantation. St. John's Wort can induce the activity of certain enzymes in the liver that metabolize cyclosporine, leading to lower levels of the drug in the blood and reduced efficacy. This can increase the risk of graft rejection and complications. The nurse should inform the healthcare provider and educate the client about the potential interaction and the importance of avoiding St. John's Wort and other herbal products without consulting the provider.

Choice B reason: This is not significant information about this finding. Adding the herb can not decrease the need for corticosteroids, which are another type of immunosuppressant drug that are used to prevent organ rejection after transplantation. St. John's Wort does not have any anti-inflammatory or immunomodulatory effects that can reduce the dosage or frequency of corticosteroids. On the contrary, it can interfere with the metabolism and absorption of corticosteroids, as well as other medications, and cause adverse effects or reduced efficacy. The nurse should advise the client to follow the prescribed regimen of corticosteroids and other drugs, and not to self-medicate with herbal products.

Choice C reason: This is not significant information about this finding. The client probably used this herb to treat depression, which is a common condition among transplant recipients, due to the stress, anxiety, and lifestyle changes associated with the procedure. However, this does not explain the cause of the graft rejection, nor does it justify the use of St. John's Wort without consulting the healthcare provider. St. John's Wort is not a proven or safe treatment for depression, and it can interact with many antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRIs), and cause serious side effects, such as serotonin syndrome. The nurse should assess the client's mental health status and refer the client to a mental health professional if needed.

Choice D reason: This is not a significant information about this finding. Ingestion of St. John's Wort can not reduce the client's intake of sodium, which is an electrolyte that is essential for the fluid balance and nerve function in the body. St. John's Wort does not have any diuretic or sodium-lowering effects that can affect the sodium levels in the blood or urine. The nurse should monitor the client's sodium levels and fluid intake and output, and report any abnormal findings to the healthcare provider. The nurse should also teach the client about the dietary sources and recommendations of sodium, and the signs and symptoms of hyponatremia or hypernatremia.

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A client with atrial fibrillation receives a new prescription for dabigatran. Which instruction should the nurse include in this client's teaching plan?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

The nurse is planning care for a client with major depression who is receiving a new prescription for duloxetine. Which information is most important for the nurse to obtain?

Correct Answer is B

Explanation

Correct Answer is A

Explanation

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